Katherine E. Prater
University of Washington
7 Papers
9 Citations
Katherine E. Prater is an academic researcher from University of Washington. The author has contributed to research in topics: Microglia & Downregulation and upregulation. The author has an hindex of 2, co-authored 7 publications.
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Papers
Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype.
Susan Fung,Carole L. Smith,Katherine E. Prater,Amanda Case,Kevin Green,Leah Osnis,Chloe N. Winston,Yoshito Kinoshita,Bryce L. Sopher,Richard S. Morrison,Gwenn A. Garden,Suman Jayadev +11 more
TL;DR: The findings demonstrate that PSEN2 N141I heterozygosity is associated with disrupted innate immune homeostasis, suggesting EOFAD variants may promote disease progression through non-neuronal cells beyond canonical dysregulated Aβ production.
Half-Life Your Message: A Quick, Flexible Tool for Message Discovery:
TL;DR: A tool, called “Half-Life Your Message,” is described, which is adapted from a commonly used improvisational theater game and can be applied in three minutes to distill a central thesis for any communication effort.
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A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors.
Katherine E. Prater,Macarena S. Aloi,Jasmine L. Pathan,Chloe N. Winston,Rachel A. Chernoff,Stephanie Davidson,Matthew P. Sadgrove,Ashley McDonough,Dannielle Zierath,Wei Su,Jonathan Weinstein,Gwenn A. Garden +11 more
TL;DR: In this paper, the authors identify Prominin-1 (Prom1; also known as CD133) as a putative cell surface marker of committed brain myeloid progenitor cells and demonstrate that Prom1-expressing cells isolated from mixed cortical cultures will generate new microglia in vitro.
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Subtype transcriptomic profiling of myeloid cells in Alzheimer Disease brain illustrates the diversity in active microglia phenotypes
Katherine E. Prater,Kevin Green,Carole L. Smith,Wei Sun,Kenneth L Chiou,Laura Heath,Shannon E. Rose,Ali Shojaie,Noah Snyder-Mackler,C. Dirk Keene,Elizabeth Blue,Jessica E. Young,Benjamin A. Logsdon,Gwenn A. Garden,Suman Jayadev +14 more
TL;DR: In this article, the authors performed single-nucleus RNA-seq on more than 120,000 microglia nuclei from AD and control dorsolateral prefrontal cortex and found that three internalization and trafficking subtypes were heterogeneous in their metabolic and inflammatory signatures and one of these endolysosomal subtypes is larger in AD individuals and was uniquely enriched for genes involved in nucleic acid detection and activation of interferon signaling.
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