Jessica E. Young
University of Washington
98 Papers
187 Citations
Jessica E. Young is an academic researcher from University of Washington. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 67 publications. Previous affiliations of Jessica E. Young include University of Otago & University of California, San Diego.
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Papers
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho Lim Fung,Jessica E. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa L. Wilbert,Junying Yu,Ewen F. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James A. Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
Evan Hermel,Evan Hermel,Juliette Gafni,Stephanie S. Propp,Blair R. Leavitt,Cheryll Wellington,Jessica E. Young,Abigail S. Hackam,Anna Logvinova,Alyson Peel,Sylvia F. Chen,Vivian Hook,Roshni R. Singaraja,Stan Krajewski,Paul C. Goldsmith,H M Ellerby,Michael R. Hayden,Dale E. Bredesen,Dale E. Bredesen,Lisa M. Ellerby +19 more
TL;DR: Upregulation of caspase-2 correlates directly with decreased levels of brain-derived neurotrophic factor in the cortex and striatum of 3-month YAC72 transgenic mice and therefore suggests that these changes are early events in HD pathogenesis.
Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA
Constanza J. Cortes,Helen C. Miranda,Harald Frankowski,Yakup Batlevi,Jessica E. Young,Amy Le,Nishi Ivanov,Bryce L. Sopher,Cassiano Carromeu,Alysson R. Muotri,Gwenn A. Garden,Albert R. La Spada +11 more
TL;DR: It is found that polyQ-AR reduced long-term protein turnover and impaired autophagic flux in motor neuron–like cells and diminishes TFEB function to impair autophagy and promote SBMA pathogenesis.
Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing
Allison Knupp,Swati Mishra,Refugio A. Martinez,Jacquelyn E. Braggin,Marcell Szabo,Chizuru Kinoshita,Dale W. Hailey,Scott A. Small,Suman Jayadev,Jessica E. Young +9 more
TL;DR: Inhibition of BACE does not rescue endosome enlargement in SORL1-deficient neurons, suggesting that this phenotype is independent of amyloidogenic APP processing, and underscores how sporadic AD pathways regulating endosomal trafficking and autosomal-dominant AD pathways regulate APP cleavage independently converge on the defining cytopathology of AD.
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Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.
TL;DR: The authors showed that nutrient deprivation can be used to understand the regulatory basis of neuronal autophagy and implicate diminished insulin signaling in the activation of neuronal auto-pathway, and showed that 3-methyl-adenine treatment and Atg5 RNA interference knockdown each inhibits LC3I to LC3-II conversion.
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