Jonathon Snook
2 Papers
Jonathon Snook is an academic researcher. The author has contributed to research in topics: Infliximab & Adalimumab. The author has an hindex of 2, co-authored 2 publications.
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Papers
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Nicholas A. Kennedy,Nicholas A. Kennedy,Nicholas A. Kennedy,Graham A. Heap,Harry D Green,Benjamin Hamilton,Claire Bewshea,Gareth J. Walker,Amanda Thomas,Rachel Nice,Mandy H Perry,Sonia Bouri,Neil Chanchlani,Neel Heerasing,Peter Hendy,Simeng Lin,Daniel R. Gaya,J R Fraser Cummings,J R Fraser Cummings,Christian P. Selinger,Charlie W. Lees,Charlie W. Lees,Ailsa L. Hart,Miles Parkes,Shaji Sebastian,John C Mansfield,Peter M. Irving,James O. Lindsay,Richard K Russell,Timothy J. McDonald,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie W. Lees,Gareth R. Jones,James W Hart,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil Shah,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C. Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +160 more
TL;DR: Clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal are identified.
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HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease
Aleksejs Sazonovs,Nicholas A Kennedy,Nicholas A Kennedy,Loukas Moutsianas,Graham A. Heap,Graham A. Heap,Daniel L. Rice,Mark Reppell,Claire Bewshea,Neil Chanchlani,Neil Chanchlani,Gareth J. Walker,Gareth J. Walker,Mandy H Perry,Timothy J. McDonald,Charlie W. Lees,J R Fraser Cummings,J R Fraser Cummings,Miles Parkes,John C. Mansfield,Peter M. Irving,Jeffrey C. Barrett,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Carl A. Anderson,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie Lees,Gareth T. Jones,James W Hart,Daniel R. Gaya,Richard K. Russell,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Shaji Sebastian,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Christian P. Selinger,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O. Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil P. Shah,Sonia Bouri,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Fraser Cummings,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +159 more
TL;DR: In an observational study, a genome-wide significant association between HLA-DQA1*05 and the development of antibodies against anti-TNF agents is found and a randomized controlled biomarker trial is required to determine whether pretreatment testing for HLA*05 improves patient outcomes by helping physicians select anti- TNF and combination therapies.
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