Christopher J. Hawkey
University of Nottingham
432 Papers
5.1K Citations
Christopher J. Hawkey is an academic researcher from University of Nottingham. The author has contributed to research in topics: Medicine & Aspirin. The author has an hindex of 87, co-authored 418 publications. Previous affiliations of Christopher J. Hawkey include Queen's University & Nottingham University Hospitals NHS Trust.
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Papers
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis
Claire Bombardier,Loren Laine,Alise S. Reicin,Deborah R. Shapiro,Ruben Burgos-Vargas,Barry R. Davis,Richard O. Day,Marcos Bosi Ferraz,Christopher J. Hawkey,Marc C. Hochberg,Tore K Kvien,Thomas J. Schnitzer +11 more
TL;DR: In patients with rheumatoid arthritis, treatment with rofecoxib, a selective inhibitor of cyclooxygenase-2, is associated with significantly fewer clinically important upper gastrointestinal events than treatment with naproxen, a nonselective inhibitor.
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials
Colin Baigent,Neeraj Bhala,Jonathan Emberson,A Merhi,S. Abramson,Nadir Arber,John A. Baron,Claire Bombardier,Christopher P. Cannon,Michael E. Farkouh,Garret A. FitzGerald,Paul E. Goss,Heather Halls,Ernest T. Hawk,Christopher J. Hawkey,C H Hennekens,Marc C. Hochberg,Lisa Holland,Patricia M. Kearney,Loren Laine,Angel Lanas,Peter Lance,Andreas Laupacis,Jim C. Oates,Carlo Patrono,Thomas J. Schnitzer,Scott D. Solomon,Peter Tugwell,Kate Wilson,Janet Wittes,O. Adelowo,P. Aisen,Abdulaziz A Al-Quorain,Roy D. Altman,George L. Bakris,H. Baumgartner,C. Bresee,M. Carducci,D. M. Chang,C. T. Chou,D. Clegg,M. Cudkowicz,L. Doody,Y. El Miedany,Claire Falandry,J. Farley,Leslie G. Ford,M. Garcia-Losa,M. Gonzalez-Ortiz,M. Haghighi,M. Hala,T. Iwama,Zrinka Jajić,David J. Kerr,H. S. Kim,C.-H. Köhne,B. K. Koo,Barbara K. Martin,Curtis L. Meinert,N. Muller,G. Myklebust,D. Neustadt,R. Omdal,S. Ozgocmen,A. Papas,Paola Patrignani,F. Pelliccia,V. Roy,I. Schlegelmilch,Asad Umar,O. Wahlstrom,F. Wollheim,S. Yocum,X. Y. Zhang,E. Hall,Patricia McGettigan,R Midgley,R. A. Moore,R. Philipson,Sean P. Curtis,Alise S. Reicin,John H. Bond,Ami R. Moore,M. Essex,J. Fabule,B. Morrison,Leslie Tive,Kelly Davies,F. Yau +88 more
TL;DR: Although NSAIDs increase vascular and gastrointestinal risks, the size of these risks can be predicted, which could help guide clinical decision making.
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Katrina M. de Lange,Loukas Moutsianas,James Lee,Christopher A. Lamb,Yang Luo,Yang Luo,Yang Luo,Nicholas A. Kennedy,Luke Jostins,Luke Jostins,Daniel L. Rice,Javier Gutierrez-Achury,Sun-Gou Ji,Graham A. Heap,Elaine R. Nimmo,Cathryn Edwards,Paul Henderson,Paul Henderson,Craig Mowat,Jeremy D. Sanderson,Jack Satsangi,Alison Simmons,Alison Simmons,David C. Wilson,David C. Wilson,Mark Tremelling,Ailsa Hart,Christopher G. Mathew,Christopher G. Mathew,William G. Newman,William G. Newman,Miles Parkes,Charlie W. Lees,Holm H. Uhlig,Christopher J. Hawkey,Natalie J. Prescott,Tariq Ahmad,John C. Mansfield,Carl A. Anderson,Jeffrey C. Barrett +39 more
TL;DR: This work identified 25 new susceptibility loci, 3 of which contain integrin genes that encode proteins in pathways that have been identified as important therapeutic targets in inflammatory bowel disease and identified 3 associated variants that are correlated with expression changes in response to immune stimulus at two of these genes.
COX-2 inhibitors
TL;DR: The demonstration that inhibition of prostaglandin synthesis via a cyclo-oxygenase (COX) enzyme was central to both the therapeutic and toxic effects of aspirin and non-aspirin NSAIDs appeared to establish the principle of no gain without pain, but this link may have been broken by drugs that selectively inhibit the inducible COX-2 enzyme.
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