Jeffry Alexander
Virginia Commonwealth University
5 Papers
35 Citations
Jeffry Alexander is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Alcohol dependence & Single-nucleotide polymorphism. The author has an hindex of 4, co-authored 4 publications.
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Papers
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Emma C. Johnson,Ditte Demontis,Thorgeir E. Thorgeirsson,Raymond K. Walters,Renato Polimanti,Alexander S. Hatoum,Sandra Sanchez-Roige,Sarah E. Paul,Frank R. Wendt,Toni-Kim Clarke,Dongbing Lai,Gunnar W Reginsson,Hang Zhou,June He,David A.A. Baranger,Daniel F. Gudbjartsson,Robbee Wedow,Daniel E. Adkins,Amy E. Adkins,Jeffry Alexander,Silviu-Alin Bacanu,Tim B. Bigdeli,Joseph M. Boden,Sandra A. Brown,Kathleen K. Bucholz,Jonas Bybjerg-Grauholm,Robin P. Corley,Louisa Degenhardt,Danielle M. Dick,Benjamin W. Domingue,Louis Fox,Alison Goate,Scott D. Gordon,Laura M. Hack,Dana B. Hancock,Sarah M. Hartz,Ian B. Hickie,David M. Hougaard,Kenneth Krauter,Penelope A. Lind,Jeanette N. McClintick,Matthew B. McQueen,Jacquelyn L. Meyers,Grant W. Montgomery,Ole Mors,Preben Bo Mortensen,Merete Nordentoft,John F. Pearson,Roseann E. Peterson,Maureen Reynolds,John P. Rice,Valgerdur Runarsdottir,Nancy L. Saccone,Richard Sherva,Judy L. Silberg,Ralph E. Tarter,Thorarinn Tyrfingsson,Tamara L. Wall,Bradley T. Webb,Thomas Werge,Leah Wetherill,Margaret J. Wright,Stephanie Zellers,Mark Adams,Laura J. Bierut,Jason D. Boardman,William E. Copeland,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Richard A. Grucza,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Kenneth S. Kendler,Martin A. Kennedy,Henry R. Kranzler,Pamela A. F. Madden,Hermine H. Maes,Brion S. Maher,Nicholas G. Martin,Matt McGue,Andrew M. McIntosh,Sarah E. Medland,Elliot C. Nelson,Bernice Porjesz,Brien P. Riley,Michael C. Stallings,Michael M. Vanyukov,Scott I. Vrieze,Lea K. Davis,Ryan Bogdan,Joel Gelernter,Howard J. Edenberg,Kari Stefansson,Anders D. Børglum,Arpana Agrawal +101 more
TL;DR: These findings support the theory that Cannabis use disorder has shared genetic liability with other psychopathology, and there is a distinction between genetic liability to cannabis use and cannabis use disorder.
296
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
Po-Hsiu Kuo,Po-Hsiu Kuo,Gursharan Kalsi,Carol A. Prescott,Colin A. Hodgkinson,David Goldman,Jeffry Alexander,Edwin J. C. G. van den Oord,Xiangning Chen,Patrick F. Sullivan,Diana G. Patterson,Dermot Walsh,Kenneth S. Kendler,Brien P. Riley +13 more
TL;DR: The findings suggest that the underlying pathophysiology regulated by genes like GAD1 may be more directly related to the component processes that form AD than to the clinical disorder.
36
Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach
Amanda Elswick Gentry,Jeffry Alexander,Mohammad Ahangari,Roseann E. Peterson,Michael A. Miles,Jill C. Bettinger,Andrew G. Davies,Mike Groteweil,Silviu Alin Bacanu,Kenneth S. Kendler,Brien P. Riley,Bradley T. Webb +11 more
TL;DR: A novel analysis method to leverage a case only design and Whole Exome Sequencing of severe AD cases from Ireland in order to quantify the difference in functional variation between ethanol-metabolizing genes and their matched controls demonstrates a computationally viable and statistically appropriate approach for genetic analysis of case-only data.
2
A systematic gene-based screen of chr4q22–q32 identifies association of a novel susceptibility gene, DKK2 , with the quantitative trait of alcohol dependence symptom counts
Gursharan Kalsi,Po-Hsiu Kuo,Fazil Aliev,Fazil Aliev,Jeffry Alexander,Omari McMichael,Diana G. Patterson,Dermot Walsh,Zhongming Zhao,Marc A. Schuckit,John Jr Nurnberger,Howard J. Edenberg,John Kramer,Vladimir I. Vladimirov,Carol A. Prescott,Danielle M. Dick,Kenneth S. Kendler,Brien P. Riley +17 more
TL;DR: A systematic, gene-centric association study using 518 LD-tagging single nucleotide polymorphisms in the 65 known and predicted genes within the 1-LOD interval surrounding the linkage peak, which yielded empirical evidence of association with two genes, DKK2 (dickkopf homolog 2) and EGF (epidermal growth factor) in the IASPSAD sample.
Association of ADH and ALDH Genes With Alcohol Dependence in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) Sample
Po-Hsiu Kuo,Gursharan Kalsi,Carol A. Prescott,Colin A. Hodgkinson,David Goldman,Edwin J. C. G. van den Oord,Jeffry Alexander,Cizhong Jiang,Patrick F. Sullivan,Diana G. Patterson,Dermot Walsh,Kenneth S. Kendler,Brien P. Riley +12 more
TL;DR: The significant interaction effects between markers in ADH and ALDH genes suggest possible epistatic roles between alcohol metabolic enzymes in the risk for AD.