J. A. Cole
University of Birmingham
51 Papers
806 Citations
J. A. Cole is an academic researcher from University of Birmingham. The author has contributed to research in topics: Escherichia coli & Nitrite reductase. The author has an hindex of 24, co-authored 48 publications.
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Papers
Modulation of Shigella virulence in response to available oxygen in vivo
Benoit S. Marteyn,Nicholas P. West,Nicholas P. West,Douglas F. Browning,J. A. Cole,Jonathan G. Shaw,Fredrik Palm,Joëlle Mounier,Marie-Christine Prévost,Philippe J. Sansonetti,Philippe J. Sansonetti,Christoph M. Tang +11 more
TL;DR: There is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.
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Cytidine 5'-monophospho-N-acetylneuraminic acid or a related compound is the low Mr factor from human red blood cells which induces gonococcal resistance to killing by human serum.
TL;DR: N nanogram quantities of a commercial preparation of cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NANA) were shown to induce gonococci to serum resistance, and the two materials were indistinguishable in their patterns of acid and heat lability.
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Sialylation of lipopolysaccharide and loss of absorption of bactericidal antibody during conversion of gonococci to serum resistance by cytidine 5'-monophospho-N-acetyl neuraminic acid.
TL;DR: It is concluded that serum resistance conferred on gonococci by CMP-NANA is due to transfer of sialyl groups to surface LPS sites and this inhibits their reaction with bactericidal antibody in human serum.
110
A reassessment of the range of c-type cytochromes synthesized by Escherichia coli K-12
Chantal Iobbi-Nivol,Helen Crooke,Lesley Griffiths,Jane I. Grove,Haitham Hussain,Janine Pommier,Vincent Méjean,J. A. Cole +7 more
TL;DR: Five different c-type cytochromes have been detected during anaerobic growth of various Escherichia coli strains in different media, but none of these cyto Chromes was detectable in aerobically-grown cultures.
96
Distribution of a lipooligosaccharide-specific sialyltransferase in pathogenic and non-pathogenic Neisseria.
TL;DR: Sialyltransferase activity has been detected in Triton X100 extracts of all examined strains of pathogenic Neisseria as well as in 17 out of 18Neisseria lactamica isolates and in some strains which lack this component.
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