Ignacio Munoz-Sanjuan
Merck & Co.
16 Papers
93 Citations
Ignacio Munoz-Sanjuan is an academic researcher from Merck & Co.. The author has contributed to research in topics: Neurogenesis & Progenitor cell. The author has an hindex of 8, co-authored 16 publications. Previous affiliations of Ignacio Munoz-Sanjuan include CHDI Foundation.
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Papers
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications
James G. Bilsland,Alan Wheeldon,Andrew Mead,Petr Znamenskiy,Sarah Almond,Kerry A. Waters,Matthew Thakur,Vahri Beaumont,Timothy P. Bonnert,Robert P. Heavens,Paul J. Whiting,George McAllister,Ignacio Munoz-Sanjuan +12 more
TL;DR: It is suggested that ALK functions in the adult brain to regulate the function of the frontal cortex and hippocampus and identifies ALK as a new target for psychiatric indications, such as schizophrenia and depression, with an underlying deregulated monoaminergic signalling.
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Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation.
Timothy P. Bonnert,James G. Bilsland,Paul C. Guest,Robert P. Heavens,Donna McLaren,Charlotte Dale,Matthew Thakur,George McAllister,Ignacio Munoz-Sanjuan +8 more
TL;DR: RNA profiling of adult SVZ cell cultures undergoing differentiation is carried out to identify pathways that regulate progenitor cell proliferation and to define a set of transcripts that can be used as molecular tools in the drug discovery process.
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A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.
James G. Bilsland,Christine Haldon,Julie Goddard,Kevin R. Oliver,Fraser Murray,Alan Wheeldon,Janine Cumberbatch,George McAllister,Ignacio Munoz-Sanjuan +8 more
TL;DR: A robust and rapid means of quantifying BrdU labelling in adult hippocampus in vivo would allow higher throughput screening of potential antidepressant compounds and offer a more rapid and streamlined means to quantify effects of compounds on hippocampal proliferation.
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Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment.
Heather A. Skynner,Doran P. Amos,Fraser Murray,Kamran Salim,M.R. Knowles,Ignacio Munoz-Sanjuan,Luis M. Camargo,Timothy P. Bonnert,Paul C. Guest +8 more
TL;DR: Ingenuity Pathways Analysis of the canonical signaling pathways showed that glycolysis and gluconeogenesis were altered in the hypothalamus and the hippocampus and all three brain regions showed changes in phenylalanine, glutamate and nitrogen metabolism.
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Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease.
TL;DR: There is a pressing need to improve the use of existing HD models and also to develop models in higher species beyond rodent, such as sheep, minipig, and nonhuman primate, to bridge the translational gap from preclinical to clinical testing of candidate therapeutics.
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