Alan Wheeldon
Merck & Co.
19 Papers
254 Citations
Alan Wheeldon is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of Alan Wheeldon include Merck Sharp & Dohme Federal Credit Union.
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Papers
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications
James G. Bilsland,Alan Wheeldon,Andrew Mead,Petr Znamenskiy,Sarah Almond,Kerry A. Waters,Matthew Thakur,Vahri Beaumont,Timothy P. Bonnert,Robert P. Heavens,Paul J. Whiting,George McAllister,Ignacio Munoz-Sanjuan +12 more
TL;DR: It is suggested that ALK functions in the adult brain to regulate the function of the frontal cortex and hippocampus and identifies ALK as a new target for psychiatric indications, such as schizophrenia and depression, with an underlying deregulated monoaminergic signalling.
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Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs
Nadia M.J. Rupniak,Emma J. Carlson,J.K. Webb,T. Harrison,R.D. Porsolt,S. Roux,C. de Felipe,SP Hunt,B. Oates,Alan Wheeldon +9 more
TL;DR: Previous observations on the phenotype of the NK1R−/− mouse are extended and a broadly similar profile following acute pharmacological blockade of the receptor is established, to underscore the limitations of currently available antagonists that are suitable for use in rat and mouse behavioural assays.
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Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.
Karen A. Maubach,Karine Martin,Gary G. Chicchi,T. Harrison,Alan Wheeldon,Christopher John Swain,Michael J Cumberbatch,Nadia M.J. Rupniak,Guy R. Seabrook +8 more
TL;DR: Chronic, but not acute, treatment with the substance P receptor antagonist L-760735, induced burst firing of neurones in the locus coeruleus, which resembles that of the conventional antidepressant imipramine, but their effects are dissociable.
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A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.
James G. Bilsland,Christine Haldon,Julie Goddard,Kevin R. Oliver,Fraser Murray,Alan Wheeldon,Janine Cumberbatch,George McAllister,Ignacio Munoz-Sanjuan +8 more
TL;DR: A robust and rapid means of quantifying BrdU labelling in adult hippocampus in vivo would allow higher throughput screening of potential antidepressant compounds and offer a more rapid and streamlined means to quantify effects of compounds on hippocampal proliferation.
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Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.
Gregori J. Morriello,Robert J. DeVita,Sander G. Mills,Jonathan R. Young,Peter Lin,George A. Doss,Gary G. Chicchi,Julie A. DeMartino,Marc M. Kurtz,Kwei-Lan C. Tsao,Emma J. Carlson,Karen Townson,Alan Wheeldon,Susan Boyce,Neil Collinson,Nadia M.J. Rupniak,Stephen Moore +16 more
TL;DR: The discovery and preparation of a novel 5,5-fused pyrrolidine core is presented, which maintains the excellent binding affinity and functional IP activity of the previously reported compounds, but also exhibits excellent brain penetration as observed in a gerbil foot-tapping assay.
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