Iain J. Gallagher
University of Stirling
62 Papers
143 Citations
Iain J. Gallagher is an academic researcher from University of Stirling. The author has contributed to research in topics: Skeletal muscle & Internal medicine. The author has an hindex of 22, co-authored 58 publications. Previous affiliations of Iain J. Gallagher include Royal Veterinary College & Edinburgh Royal Infirmary.
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Papers
High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression
Peter K. Davidsen,Peter K. Davidsen,Iain J. Gallagher,Joseph W. Hartman,Mark A. Tarnopolsky,Flemming Dela,Jørn Wulff Helge,James A. Timmons,James A. Timmons,Stuart M. Phillips +9 more
TL;DR: It is reported, for the first time, that RT-induced hypertrophy in human skeletal muscle is associated with selected changes in miRNA abundance and the analysis indicates that miRNAs may play a role in the phenotypic change and pronounced intergroup variation in the RT response.
373
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
Iain J. Gallagher,Camilla Scheele,Camilla Scheele,Pernille Keller,Pernille Keller,Anders R. Nielsen,Judit Remenyi,Christian P. Fischer,Karim Roder,John A. Babraj,Claes Wahlestedt,Gyorgy Hutvagner,Bente Klarlund Pedersen,James A. Timmons +13 more
TL;DR: It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner, and miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions.
305
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection
P'ng Loke,Iain J. Gallagher,Meera G. Nair,Meera G. Nair,Xingxing Zang,Frank Brombacher,Markus Mohrs,James P. Allison,Judith E. Allen +8 more
TL;DR: Evidence is presented that alternative activation by type 2 cytokines is an innate response to injury that can occur in the absence of an adaptive response, and AAMΦ show enhanced phagocytosis of apoptotic neutrophils, but not latex beads.
294
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Pernille Keller,Niels B. J. Vollaard,Thomas Gustafsson,Iain J. Gallagher,Carl Johan Sundberg,Tuomo Rankinen,Steven L. Britton,Claude Bouchard,Lauren G. Koch,James A. Timmons,James A. Timmons +10 more
TL;DR: This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption and found that both the TRT and a homologous subset of the human high responder genes were regulated to a greater degree in high respondser rodent skeletal muscle.
257
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
Sanjana Sood,Iain J. Gallagher,Katie Lunnon,Katie Lunnon,Eric Rullman,Aoife Keohane,Hannah Crossland,Bethan E. Phillips,Tommy Cederholm,Thomas E. Jensen,Luc J. C. van Loon,Lars Lannfelt,William E. Kraus,Philip J. Atherton,Robert Howard,Thomas Gustafsson,Angela Hodges,James A. Timmons +17 more
TL;DR: A novel and statistically robust multi-tissue RNA signature of human healthy ageing that can act as a diagnostic of future health, using only a peripheral blood sample is identified.