John A. Babraj
Abertay University
57 Papers
100 Citations
John A. Babraj is an academic researcher from Abertay University. The author has contributed to research in topics: Sprint & Interval training. The author has an hindex of 23, co-authored 53 publications. Previous affiliations of John A. Babraj include University of Dundee & Heriot-Watt University.
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Papers
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Daniel J. Cuthbertson,Kenneth Smith,Kenneth Smith,John A. Babraj,Graham P. Leese,T Waddell,Philip J. Atherton,Philip J. Atherton,Henning Wackerhage,Peter M. Taylor,M. J. Rennie,M. J. Rennie +11 more
TL;DR: It is demonstrated that EAA stimulate MPS independently of increased insulin availability, and in the elderly, a deficit in MPS in the basal state is unlikely; and the decreased sensitivity and responsiveness of MPS to EAA, associated with decrements in the expression and activation of components of anabolic signaling pathways, are probably major contributors to the failure of muscle maintenance inThe elderly.
1.2K
Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise
Benjamin F. Miller,Jens Lykkegaard Olesen,Mette Hansen,Simon Døssing,Regina M. Crameri,Rasmus J. Welling,Henning Langberg,Allan Flyvbjerg,Michael Kjaer,John A. Babraj,Kenneth Smith,Kenneth Smith,Michael J. Rennie,Michael J. Rennie +13 more
TL;DR: There is a rapid increase in collagen synthesis after strenuous exercise in human tendon and muscle, and the similar time course of changes of protein synthetic rates in different cell types supports the idea of coordinated musculotendinous adaptation.
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Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
Philip J. Atherton,Philip J. Atherton,Philip J. Atherton,John A. Babraj,Kenneth Smith,Jaipaul Singh,Michael J. Rennie,Henning Wackerhage +7 more
TL;DR: The data suggest that a specific signaling response to LFS is a specific activation of the AMPK‐PGC‐1α signaling pathway which may explain some endurance training adaptations.
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Extremely short duration high intensity interval training substantially improves insulin action in young healthy males
John A. Babraj,Niels B. J. Vollaard,Cameron Keast,Fergus M. Guppy,Greg Cottrell,James A. Timmons,James A. Timmons +6 more
TL;DR: The efficacy of a high intensity exercise protocol, involving only ~250 kcal of work each week, to substantially improve insulin action in young sedentary subjects is remarkable and can be used as a strategy to reduce metabolic risk factors in young and middle aged sedentary populations who otherwise would not adhere to time consuming traditional aerobic exercise regimes.
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
Iain J. Gallagher,Camilla Scheele,Camilla Scheele,Pernille Keller,Pernille Keller,Anders R. Nielsen,Judit Remenyi,Christian P. Fischer,Karim Roder,John A. Babraj,Claes Wahlestedt,Gyorgy Hutvagner,Bente Klarlund Pedersen,James A. Timmons +13 more
TL;DR: It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner, and miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions.
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