Franziska Müller
Max Planck Society
20 Papers
40 Citations
Franziska Müller is an academic researcher from Max Planck Society. The author has contributed to research in topics: Microtubule & Biology. The author has an hindex of 8, co-authored 12 publications.
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Papers
Basis of catalytic assembly of the mitotic checkpoint complex
Alex C. Faesen,Maria Thanasoula,Stefano Maffini,Claudia Breit,Franziska Müller,Suzan van Gerwen,Tanja Bange,Andrea Musacchio +7 more
TL;DR: A near-complete SAC signalling system with purified components and monitored assembly of the MCC in real time is reconstituted and catalytic activation of the SAC depends on regulated protein–protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for MCC assembly.
Direct Equilibration and Characterization of Polymer Melts for Computer Simulations
TL;DR: In this paper, a methodology to prepare well-equilibrated polymer melts which only requires local relaxation is presented, which efficiently leads to equilibrate ensembles of bead-spring polymer melts of 1'000 chains of up to 2'000 beads.
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BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
Katharina Overlack,Tanja Bange,Florian Weissmann,Alex C. Faesen,Stefano Maffini,Ivana Primorac,Franziska Müller,Jan-Michael Peters,Andrea Musacchio,Andrea Musacchio +9 more
TL;DR: Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the SAC signaling cascade, suggesting that BubR 1:Bub3 recognition and inhibition of APC/C requires phosphorylation.
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Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
Arnaud Rondelet,Yu-Chih Lin,Divya Singh,Arthur T. Porfetye,Harish C. Thakur,Andreas Hecker,Pia Brinkert,Nadine Schmidt,Shweta Bendre,Franziska Müller,Lisa Mazul,Per O. Widlund,Tanja Bange,Michael Hiller,Ingrid R. Vetter,Alexander W. Bird +15 more
TL;DR: The clathrin–adaptor interaction mechanism is repurposed to recruit GTSE1 to the spindle, which inhibits the microtubule depolymerase MCAK and promotes chromosome alignment by stabilizing nonkinetochore microtubules.
Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
TL;DR: This work uncovers a mechanism revealing that Cdk1 destabilizes astral microtubules in prometaphase and thereby influences spindle reorientation, a state assisted by selective destabilization of long astralmicrotubules via Cdk 1.
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