Jan-Michael Peters
Research Institute of Molecular Pathology
208 Papers
1.8K Citations
Jan-Michael Peters is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Cohesin & Establishment of sister chromatid cohesion. The author has an hindex of 93, co-authored 195 publications. Previous affiliations of Jan-Michael Peters include Harvard University & Medical University of Vienna.
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Papers
How proteolysis drives the cell cycle
TL;DR: Proteolysis drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics, and also how proteolysis may directly trigger the transition from metaphase to anaphase.
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The anaphase promoting complex/cyclosome: a machine designed to destroy
TL;DR: Recent discoveries have revealed an unexpected multitude of mechanisms that control APC/C activity, and have provided a first insight into how this unusual ubiquitin ligase recognizes its substrates.
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Silke Hauf,Richard W. Cole,Sabrina LaTerra,Christine Zimmer,Gisela Schnapp,Rainer Walter,Armin Heckel,Jacques van Meel,Conly L. Rieder,Jan-Michael Peters +9 more
TL;DR: The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
Randall W. King,Jan-Michael Peters,Stuart Tugendreich,Mark Rolfe,Philip Hieter,Marc W. Kirschner +5 more
TL;DR: It is found that UBC4 and at least one other ubiquitin-conjugating enzyme can support cyclin B ubiquitination and suggested that APC functions as a regulated ubiquitIn-protein ligase that targets cyclin A for destruction in mitosis.
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The anaphase-promoting complex: proteolysis in mitosis and beyond.
TL;DR: Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin- dependent proteolysis, mediated by the anaphase-promoting complex.
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