Frank M. Longo
Stanford University
168 Papers
2.7K Citations
Frank M. Longo is an academic researcher from Stanford University. The author has contributed to research in topics: Neurotrophin & Neurite. The author has an hindex of 56, co-authored 153 publications. Previous affiliations of Frank M. Longo include University of California, San Francisco & City of Hope National Medical Center.
Chat about Author
Papers
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Saul A. Villeda,Kristopher E Plambeck,Jinte Middeldorp,Joseph M. Castellano,Kira I. Mosher,Jian Luo,Lucas K. Smith,Gregor Bieri,Karin Lin,Daniela Berdnik,Rafael Wabl,Joe C. Udeochu,Elizabeth G. Wheatley,Bende Zou,Danielle A. Simmons,Xinmin Xie,Frank M. Longo,Tony Wyss-Coray +17 more
TL;DR: Exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function, and structural and cognitive enhancements elicited by exposure are mediated by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus.
Laminin promotes neuritic regeneration from cultured peripheral and central neurons.
TL;DR: Tissue culture methods are used to examine the relative ability of various extracellular matrix components to elicit neurite outgrowth from dissociated chick embryo parasympathetic neurons in serum-free monolayer culture and conclude that laminin and PNPF-1 are distinct macromolecules capable of expressing their neurite-promoting activities even when presented in nanogram amounts.
755
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.
Michael S. Beattie,Anthony W. Harrington,Ramee Lee,Ju Young Kim,Sheri L Boyce,Frank M. Longo,Jacqueline C. Bresnahan,Barbara L. Hempstead,Sung Ok Yoon +8 more
TL;DR: It is reported that p75 is required for the death of oligodendrocytes following spinal cord injury, and its action is mediated mainly by proNGF, which is to eliminate damaged cells by activating the apoptotic machinery of p75 after injury.
455
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas,Amira Latif-Hernandez,Melanie R. McReynolds,Aarooran Sivakumaran Durairaj,Qian Wang,Amanda J. Rubin,Amit Joshi,Joy Q He,Esha Gauba,Ling Liu,Congcong Wang,Miles H. Linde,Yuki Sugiura,Peter K. Moon,Ravi Majeti,Makoto Suematsu,Daria Mochly-Rosen,Irving L. Weissman,Frank M. Longo,Joshua D. Rabinowitz,Katrin I. Andreasson +20 more
TL;DR: This article showed that myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E2 (PGE2), a major modulator of inflammation.
364
B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke
Kristian P. Doyle,Lisa N. Quach,Montse Solé,Robert C. Axtell,Thuy-Vi V. Nguyen,Gilberto J. Soler-Llavina,Sandra Jurado,Jullet Han,Lawrence Steinman,Frank M. Longo,Julie A. Schneider,Robert C. Malenka,Marion S. Buckwalter +12 more
TL;DR: It is discovered that in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke and immunostaining of human postmortem tissue revealed that a B-LYmphocyte response to stroke also occurs in the brain of some people with stroke and dementia.
310