7 Papers
14 Citations
Karin Lin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Transgene. The author has an hindex of 4, co-authored 5 publications.
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Papers
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Saul A. Villeda,Kristopher E Plambeck,Jinte Middeldorp,Joseph M. Castellano,Kira I. Mosher,Jian Luo,Lucas K. Smith,Gregor Bieri,Karin Lin,Daniela Berdnik,Rafael Wabl,Joe C. Udeochu,Elizabeth G. Wheatley,Bende Zou,Danielle A. Simmons,Xinmin Xie,Frank M. Longo,Tony Wyss-Coray +17 more
TL;DR: Exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function, and structural and cognitive enhancements elicited by exposure are mediated by activation of the cyclic AMP response element binding protein (Creb) in the aged hippocampus.
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Lucas K. Smith,Yingbo He,Jeong Soo Park,Gregor Bieri,Cedric E. Snethlage,Karin Lin,Geraldine Gontier,Rafael Wabl,Kristopher E Plambeck,Joe C. Udeochu,Elizabeth G. Wheatley,Jill Bouchard,Alexander Eggel,Ramya Narasimha,Jacqueline L Grant,Jian Luo,Tony Wyss-Coray,Saul A. Villeda +17 more
TL;DR: In this paper, the authors identify β2-microglobulin (B2M), a component of major histocompatibility complex class 1 (MHC I) molecules, as a circulating factor that negatively regulates cognitive and regenerative function in the adult hippocampus.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.
The aged hematopoietic system promotes hippocampal‐dependent cognitive decline
Lucas K. Smith,Evgenia Verovskaya,Gregor Bieri,Alana Horowitz,Saskia N. I. von Ungern-Sternberg,Karin Lin,Peter Seizer,Emmanuelle Passegué,Saul A. Villeda +8 more
TL;DR: It is reported that aging of the hematopoietic system directly contributes to the pro‐aging effects of old blood on cognition, and a number of factors elevated in the blood of young mice reconstituted with old HSCs are identified, of which cyclophilin A (CyPA) acts as a pro-aging factor.
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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.