Fleur Jochems

TL;DR: In this article, the combination of the EGFR inhibitor gefitinib and lenvatinib displays potent anti-proliferative effects in vitro in liver cancer cell lines that express EGFR and in vivo in xenografted liver cancer cells lines, immunocompetent mouse models and patient-derived HCC tumours in mice.

TL;DR: A one-two punch approach for the treatment of cancer in which a drug is first used to induce senescence in cancer cells and a second drug is then used to kill senescent cancer cells is proposed.

TL;DR: It is found that human liver cancer was dependent on extracellular glutamine, and dual inhibition of glutamine metabolism by targeting both glutaminase and glutamine transporter ASCT2 represents a potential novel treatment strategy for glutamine addicted liver cancers.

TL;DR: In this article, a comprehensive analysis of the transcriptome and senolytic responses in a panel of 13 cancer cell lines rendered senescent by two distinct compounds was performed using machine learning, and the SENCAN gene expression classifier was used for the detection of senescence in cancer cell samples.