Fan Lin
University of Toronto
17 Papers
106 Citations
Fan Lin is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Cystic fibrosis. The author has an hindex of 8, co-authored 11 publications. Previous affiliations of Fan Lin include Hospital for Sick Children.
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Papers
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Harriet Corvol,Harriet Corvol,Scott M. Blackman,Pierre-Yves Boëlle,Paul J. Gallins,Rhonda G. Pace,Jaclyn R. Stonebraker,Frank J. Accurso,Frank J. Accurso,Annick Clement,Annick Clement,Joseph M. Collaco,Hong Dang,Anthony T. Dang,Arianna Franca,Jiafen Gong,Loïc Guillot,Katherine Keenan,Weili Li,Fan Lin,Michael V. Patrone,Karen S. Raraigh,Lei Sun,Yi-Hui Zhou,Wanda K. O'Neal,Marci K. Sontag,Marci K. Sontag,Hara Levy,Peter R. Durie,Johanna M. Rommens,Mitchell L. Drumm,Fred A. Wright,Lisa J. Strug,Garry R. Cutting,Michael R. Knowles +34 more
TL;DR: This paper used genome-wide association analysis to identify genetic modifiers of CF lung disease, the primary cause of mortality, and provided new insights into potential targets for modulating lung disease severity in CF.
Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities
Weili Li,Weili Li,David Soave,David Soave,Melissa R. Miller,Katherine Keenan,Fan Lin,Jiafen Gong,Theodore Chiang,Anne L. Stephenson,Anne L. Stephenson,Peter R. Durie,Peter R. Durie,Johanna M. Rommens,Johanna M. Rommens,Lei Sun,Lisa J. Strug,Lisa J. Strug +17 more
TL;DR: The existence of pleiotropic effects within this single disorder suggests that complementary therapeutic strategies to augment solute transport will benefit multiple CF-associated tissues.
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Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results.
Ruslan Dorfman,Weili Li,Lei Sun,Lei Sun,Fan Lin,Yongqian Wang,Andrew J. Sandford,Peter D. Paré,Karen McKay,Hana Kayserova,T. Piskackova,Milan Macek,Kamila Czerska,Dorota Sands,Harm A.W.M. Tiddens,Sonia Margarit,Gabriela M. Repetto,Marci K. Sontag,Frank J. Accurso,Scott M. Blackman,Garry R. Cutting,Lap-Chee Tsui,Lap-Chee Tsui,Mary Corey,Mary Corey,Peter Durie,Julian Zielenski,Lisa J. Strug,Lisa J. Strug +28 more
TL;DR: A modifier gene study for meconium ileus (MI), an intestinal obstruction that occurs in 16–20% of CF newborns, is conducted, providing linkage and association results from large family and case–control samples and an example of how one might overcome the confounding in the context of linkage studies.
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Modulatory effect of the SLC9A3 gene on susceptibility to infections and pulmonary function in children with cystic fibrosis
Ruslan Dorfman,Chelsea Taylor,Fan Lin,Lei Sun,Andrew J. Sandford,Peter D. Paré,Yves Berthiaume,Mary Corey,Peter R. Durie,Julian Zielenski +9 more
TL;DR: Although the functional basis for the modulatory effects of this SLC9A3 variant on CF lung disease remains to be elucidated, altered function of the Na+/H+ exchanger may further deplete the airway liquid surface, thereby enhancing susceptibility to Pseudomonas infections and worsening the severity of lung disease.
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SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion.
Saumel Ahmadi,Sunny Xia,Yu-Sheng Wu,Michelle Di Paola,Randolph Kissoon,Catherine Luk,Fan Lin,Kai Du,Johanna M. Rommens,Christine E. Bear +9 more
TL;DR: In vitro studies of mouse intestinal organoids revealed that exacerbation of the primary defect was associated with reduced arginine uptake across the apical membrane, with aberrant nitric oxide and cyclic GMP-mediated regulation of the major CF-causing mutant protein.
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