Mitchell L. Drumm
Case Western Reserve University
106 Papers
1.1K Citations
Mitchell L. Drumm is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 36, co-authored 104 publications. Previous affiliations of Mitchell L. Drumm include University Hospitals of Cleveland.
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Papers
Identification of the cystic fibrosis gene: chromosome walking and jumping.
J. Rommens,Michael C. Iannuzzi,B. Kerem,Mitchell L. Drumm,Georg Melmer,Michael Dean,R. Rozmahel,J. Cole,D. Kennedy,Noriko Hidaka,M. Zsiga,Manuel Buchwald,John R. Riordan,Lap-Chee Tsui,Francis S. Collins +14 more
TL;DR: This paper presents a meta-modelling study of the response of the immune system to repeated exposure to carbon dioxide and shows clear patterns of decline in the number of immune-related cancers over time.
357
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Harriet Corvol,Harriet Corvol,Scott M. Blackman,Pierre-Yves Boëlle,Paul J. Gallins,Rhonda G. Pace,Jaclyn R. Stonebraker,Frank J. Accurso,Frank J. Accurso,Annick Clement,Annick Clement,Joseph M. Collaco,Hong Dang,Anthony T. Dang,Arianna Franca,Jiafen Gong,Loïc Guillot,Katherine Keenan,Weili Li,Fan Lin,Michael V. Patrone,Karen S. Raraigh,Lei Sun,Yi-Hui Zhou,Wanda K. O'Neal,Marci K. Sontag,Marci K. Sontag,Hara Levy,Peter R. Durie,Johanna M. Rommens,Mitchell L. Drumm,Fred A. Wright,Lisa J. Strug,Garry R. Cutting,Michael R. Knowles +34 more
TL;DR: This paper used genome-wide association analysis to identify genetic modifiers of CF lung disease, the primary cause of mortality, and provided new insights into potential targets for modulating lung disease severity in CF.
Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.
TL;DR: The inducible isoform of nitric oxide synthase (iNOS) in the airways is examined by immunostaining and found that iNOS is constitutively expressed in theAirway epithelia of non-CF mouse and human tissues but essentially absent in the epithelium of CF airways.
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
Fred A. Wright,Lisa J. Strug,Vishal K. Doshi,Clayton W. Commander,Scott M. Blackman,Lei Sun,Yves Berthiaume,David J. Cutler,Andreea L. Cojocaru,J. Michael Collaco,Mary Corey,Ruslan Dorfman,Katrina A.B. Goddard,Deanna M. Green,Jack W. Kent,Ethan M. Lange,Seunggeun Lee,Weili Li,Jingchun Luo,Gregory Mayhew,Kathleen M. Naughton,Rhonda G. Pace,Peter D. Paré,Johanna M. Rommens,Andrew J. Sandford,Jaclyn R. Stonebraker,Wei Sun,Chelsea Taylor,Lori L. Vanscoy,Fei Zou,John Blangero,Julian Zielenski,Wanda K. O'Neal,Mitchell L. Drumm,Peter R. Durie,Michael R. Knowles,Garry R. Cutting +36 more
TL;DR: The authors' findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.
240
Cystic fibrosis–related diabetes is caused by islet loss and inflammation
Nathaniel J. Hart,Radhika Aramandla,Gregory Poffenberger,Cody Fayolle,Ariel H. Thames,Austin Bautista,Aliya F. Spigelman,Jenny Aurielle B. Babon,Megan E DeNicola,Prasanna K. Dadi,William S. Bush,Appakalai N. Balamurugan,Marcela Brissova,Chunhua Dai,Nripesh Prasad,Rita Bottino,David A. Jacobson,Mitchell L. Drumm,Sally C. Kent,Patrick E. MacDonald,Alvin C. Powers,Alvin C. Powers +21 more
TL;DR: Results indicate that CFRD is caused by β cell loss and intraislet inflammation in the setting of a complex pleiotropic disease and not by intrinsic islet dysfunction from CFTR mutation.