Dik C. van Gent
Erasmus University Rotterdam
93 Papers
498 Citations
Dik C. van Gent is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 39, co-authored 81 publications. Previous affiliations of Dik C. van Gent include Erasmus University Medical Center.
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Papers
Chromosomal stability and the DNA double-stranded break connection.
TL;DR: Interactions between both double-stranded break-repair pathways and other cellular processes, such as cell-cycle regulation and replication, are being unveiled.
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DNA double-strand break repair: from mechanistic understanding to cancer treatment.
TL;DR: This review aims to provide a foundational understanding of how the homologous recombination and non-homologous end joining pathways operate, and to demonstrate how a better understanding of these processes has advanced both the understanding of the underlying causes of cancer and the ability to innovate novel cancer treatment strategies.
711
REV7 counteracts DNA double-strand break resection and affects PARP inhibition
Guotai Xu,J. Ross Chapman,Inger Brandsma,Jingsong Yuan,Martin Mistrik,Peter Bouwman,Jirina Bartkova,Ewa Gogola,Daniël O. Warmerdam,Marco Barazas,Janneke E. Jaspers,Kenji Watanabe,Mark Pieterse,Ariena Kersbergen,Wendy Sol,Patrick H.N. Celie,Philip C. Schouten,Bram van den Broek,Ahmed Salman,Marja Nieuwland,Iris de Rink,Jorma J. de Ronde,Kees Jalink,Simon J. Boulton,Junjie Chen,Dik C. van Gent,Jiri Bartek,Jos Jonkers,Piet Borst,Sven Rottenberg,Sven Rottenberg +30 more
TL;DR: This work shows that loss of REV7 in mouse and human cell lines re-establishes CTIP-dependent end resection of DSBs in BRCA1-deficient cells, leading to HR restoration and PARP inhibitor resistance, which is reversed by ATM kinase inhibition.
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Human Rad50/Mre11 is a flexible complex that can tether DNA ends.
TL;DR: It is suggested that a unified role for R/M in multiple aspects of DNA repair and chromosome metabolism is to provide a flexible, possibly dynamic, link between DNA ends.
546
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells
Hiroshi Tauchi,Junya Kobayashi,Ken ichi Morishima,Dik C. van Gent,Takahiro Shiraishi,Nicole S. Verkaik,Diana VanHeems,Emi Ito,Asako Nakamura,Eiichiro Sonoda,Minoru Takata,Shunichi Takeda,Shinya Matsuura,Kenshi Komatsu,Kenshi Komatsu +14 more
TL;DR: The disruption of Nbs1 reduces gene conversion and sister chromatid exchanges, similar to other HR-deficient mutants, and a site-specific double-strand break repair assay showed a notable reduction of HR events following generation of such breaks in NBS1-disrupted cells.
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