Jos Jonkers
Netherlands Cancer Institute
311 Papers
1.1K Citations
Jos Jonkers is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Biology. The author has an hindex of 80, co-authored 264 publications. Previous affiliations of Jos Jonkers include Masaryk University & University of Ottawa.
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Papers
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal,Serena Nik-Zainal,Helen Davies,Johan Staaf,Manasa Ramakrishna,Dominik Glodzik,Xueqing Zou,Inigo Martincorena,Ludmil B. Alexandrov,Sancha Martin,David C. Wedge,Peter Van Loo,Young Seok Ju,Michiel M. Smid,Arie B. Brinkman,Sandro Morganella,Miriam Ragle Aure,Ole Christian Lingjærde,Anita Langerød,Markus Ringnér,Sung-Min Ahn,Sandrine Boyault,Jane E. Brock,Annegien Broeks,Adam Butler,Christine Desmedt,Luc Dirix,Serge Dronov,Aquila Fatima,John A. Foekens,Moritz Gerstung,Gerrit Gk Hooijer,Se Jin Jang,David Jones,Hyung-Yong Kim,Tari Ta King,Savitri Krishnamurthy,Hee Jin Lee,Jeong-Yeon Lee,Yang Li,Stuart McLaren,Andrew Menzies,Ville Mustonen,Sarah O’Meara,Iris Pauporté,Xavier Pivot,Colin Ca Purdie,Keiran Raine,Kamna Ramakrishnan,Germán Fg Rodríguez-González,Gilles Romieu,Anieta M. Sieuwerts,Peter Pt Simpson,Rebecca Shepherd,Lucy Stebbings,Olafur Oa Stefansson,Jon W. Teague,Stefania Tommasi,Isabelle Treilleux,Gert Van den Eynden,Peter B. Vermeulen,Anne Vincent-Salomon,Lucy R. Yates,Carlos Caldas,Laura Van't Veer,Andrew Tutt,Andrew Tutt,Stian Knappskog,Benita Kiat Tee Bk Tan,Jos Jonkers,Åke Borg,Naoto T. Ueno,Christos Sotiriou,Alain Viari,P. Andrew Futreal,Peter J. Campbell,Paul N. Span,Steven Van Laere,Sunil R. Lakhani,Jorunn E. Eyfjord,Alastair M Thompson,Ewan Birney,Hendrik G. Stunnenberg,Marc J. van de Vijver,John W.M. Martens,Anne Lise Børresen-Dale,Andrea L. Richardson,Gu Kong,Gilles Thomas,Michael R. Stratton +89 more
TL;DR: This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Patient-derived xenograft models: an emerging platform for translational cancer research.
Manuel Hidalgo,Frédéric Amant,Andrew V. Biankin,Eva Budinská,Annette T. Byrne,Carlos Caldas,Robert Clarke,Steven de Jong,Jos Jonkers,Gunhild Mari Mælandsmo,Sergio Roman-Roman,Joan Seoane,Livio Trusolino,Alberto Villanueva +13 more
TL;DR: The current state of the art in this field is summarized, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and a European consortium of PDX models is introduced.
1.6K
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.
Seth B. Coffelt,Kelly Kersten,Chris W. Doornebal,Jorieke Weiden,Kim Vrijland,Cheei-Sing Hau,Niels J. M. Verstegen,Metamia Ciampricotti,Lukas J. A. C. Hawinkels,Jos Jonkers,Karin E. de Visser +10 more
TL;DR: It is shown that tumours maximize their chance of metastasizing by evoking a systemic inflammatory cascade in mouse models of spontaneous breast cancer metastasis, and targeting this novel cancer-cell-initiated domino effect within the immune system—the γδ T cell/IL-17/neutrophil axis—represents a new strategy to inhibit metastatic disease.
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
TL;DR: The results show that inactivation of BRCA2 and of p53 combine to mediate mammary tumorigenesis, and indicate that disruption of the p53 pathway is pivotal in BRCa2-associated breast cancer.
1.1K
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
Peter Bouwman,Amal Aly,José M. Escandell,Mark Pieterse,Jirina Bartkova,Hanneke van der Gulden,Sanne Hiddingh,Maria Thanasoula,Atul Kulkarni,Qifeng Yang,Bruce G. Haffty,Johanna Tommiska,Carl Blomqvist,Ronny Drapkin,David J. Adams,Heli Nevanlinna,Jiri Bartek,Madalena Tarsounas,Shridar Ganesan,Jos Jonkers +19 more
TL;DR: This work identifies p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion, and finds reduced 53BP1 expression in subsets of sporadic triple-negative and BRCA-associated breast cancers, indicating the potential clinical implications of these findings.