Christopher J. Day
Griffith University
126 Papers
605 Citations
Christopher J. Day is an academic researcher from Griffith University. The author has contributed to research in topics: Glycan & Campylobacter jejuni. The author has an hindex of 30, co-authored 114 publications. Previous affiliations of Christopher J. Day include Royal Brisbane and Women's Hospital & RMIT University.
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Papers
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Rebecca C. Coll,James R. Hill,Christopher J. Day,Alina Zamoshnikova,Dave Boucher,Dave Boucher,Nicholas L. Massey,Jessica L. Chitty,Jessica L. Chitty,Jessica L. Chitty,James A. Fraser,Michael P. Jennings,Avril A. B. Robertson,Kate Schroder +13 more
TL;DR: It is shown that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibitingNLRP3 activation and inflammasome formation.
MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation
TL;DR: Human osteoclast formation from monocyte precursors under the action of receptor activator of nuclear factor-κB ligand (RANKL) was suppressed by granulocyte macrophage colony-stimulating factor (GM-CSF), with down-regulation of critical osteoc last-related nuclear factors.
262
Glycointeractions in bacterial pathogenesis
TL;DR: High-throughput screening technologies, such as lectin, glycan and mucin microarrays, have transformed the field by identifying new bacterial–host glycointeractions, which are crucial for colonization, persistence and disease.
249
MCP-1-induced Human Osteoclast-like Cells Are Tartrate-resistant Acid Phosphatase, NFATc1, and Calcitonin Receptor-positive but Require Receptor Activator of NFκB Ligand for Bone Resorption
Michael S. Kim,Christopher J. Day,Christina I. Selinger,Carly Magno,Sebastien Robert Stephens,Nigel Alexander Morrison +5 more
TL;DR: It is proposed that the MCP-1-induced TRAP+/CTR+ multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity.
153
The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors
Andras N. Spaan,Manouk Vrieling,Pierre Wallet,Cédric Badiou,Tamara Reyes-Robles,Elizabeth A. Ohneck,Y. Benito,Carla J. C. de Haas,Christopher J. Day,Michael P. Jennings,Gerard Lina,François Vandenesch,Kok P. M. van Kessel,Victor J. Torres,Jos A. G. van Strijp,Thomas Henry +15 more
TL;DR: Functional quantification identifies HlGAB and HlgCB as major secreted staphylococcal leukocidins and hlgAB-mediated targeting of CCR2+ cells highlights the involvement of inflammatory macrophages during S. aureus infection.