James R. Hill
University of Queensland
8 Papers
11 Citations
James R. Hill is an academic researcher from University of Queensland. The author has contributed to research in topics: Inflammasome & Diazirine. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of James R. Hill include University of Michigan.
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Papers
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Rebecca C. Coll,James R. Hill,Christopher J. Day,Alina Zamoshnikova,Dave Boucher,Dave Boucher,Nicholas L. Massey,Jessica L. Chitty,Jessica L. Chitty,Jessica L. Chitty,James A. Fraser,Michael P. Jennings,Avril A. B. Robertson,Kate Schroder +13 more
TL;DR: It is shown that MCC950 directly interacts with the Walker B motif within the NLRP3 NACHT domain, thereby blocking ATP hydrolysis and inhibitingNLRP3 activation and inflammasome formation.
Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis
TL;DR: This review takes a synthetic focus, aiming to summarize available routes, propose new avenues, and illuminate recent advances in diazirine synthesis, to provide instructive definition of the advantages and limitations of the technology.
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The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals
Timothy M. Tucey,Jiyoti Verma-Gaur,Julie Nguyen,Victoria L. Hewitt,Tricia L. Lo,Miguel Shingu-Vazquez,Avril A. B. Robertson,James R. Hill,Filomena Pettolino,Travis Clarke Beddoe,Mark E. Cooper,Thomas Naderer,Ana Traven +12 more
- 25 May 2016
TL;DR: This study characterized the C. albicans endoplasmic reticulum (ER)-mitochondrion tether ERMES and shows that the ERM ES mmm1 mutant is severely crippled in killing macrophages despite hyphal formation and normal phagocytosis and survival, and establishes promising pathogen- and host-derived therapeutic strategies.
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Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals
James R. Hill,Xia Shao,Nicholas L. Massey,Jenelle Stauff,Phillip S. Sherman,Avril A. B. Robertson,Peter J. H. Scott +6 more
TL;DR: In silico prediction tools suggest efflux transporter liabilities for MCC950 at microdoses should be taken into account when developing next generation NLRP3 inhibitors and/or PET radiotracers.
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Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe
TL;DR: A trifluoromethyl phenyl diazirine photoaffinity probe is described, called TPD-950-Br, to probe the molecular interactions of MCC950, which captures proximal species upon photo-activation and inhibits IL-1β production in an NLRP3 inhibitor assay.
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