Brice Courselaud
French Institute of Health and Medical Research
9 Papers
229 Citations
Brice Courselaud is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepcidin & Ferroportin. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Brice Courselaud include University of Rennes.
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Papers
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Christelle Pigeon,Gennady Ilyin,Brice Courselaud,Patricia Leroyer,Bruno Turlin,Pierre Brissot,Olivier Loréal +6 more
TL;DR: The data strongly suggest that the product of the new liver-specific gene HEPC might play a specific role during iron overload and exhibit additional functions distinct from its antimicrobial activity.
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Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload1
Gennady Ilyin,Brice Courselaud,Marie-Bérengère Troadec,Christelle Pigeon,Mehdi Alizadeh,Patricia Leroyer,Pierre Brissot,Olivier Loréal +7 more
TL;DR: Comparison of sequence, genomic structure, expression and iron regulation of mouse HEPC genes suggest that both HEPC1 and HEPC2 genes are involved in iron metabolism regulation but could exhibit different activities and/or play distinct roles.
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TNFα‐mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes
Anne-Laure Sérandour,Pascal Loyer,Delphine Garnier,Brice Courselaud,Nathalie Théret,Denise Glaise,Christiane Guguen-Guillouzo,Anne Corlu +7 more
TL;DR: It is highlighted that hepatocyte division is dependent on ECM deposition associated with differentiation status, and that ECM degradation signal is critical in controlling G1/S transition and Cdk1 induction, which provide new insights for understanding the unique hepatocyte proliferation control and improving regeneration in patients suffering from liver damage.
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Hepcidin in iron metabolism.
Olivier Loréal,Christelle Haziza-Pigeon,Marie-Bérengère Troadec,Lénaïck Détivaud,Bruno Turlin,Brice Courselaud,Guennadi Ilyin,Pierre Brissot +7 more
TL;DR: The regulatory mechanisms of hepcidin expression are multiple, including iron-related parameters, anemia, hypoxia, inflammation and hepatocyte function, and many physiological and pathological situations may modulate hepcIDin expression and subsequently iron metabolism.
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Iron overload promotes Cyclin D1 expression and alters cell cycle in mouse hepatocytes.
Marie-Bérengère Troadec,Brice Courselaud,Lénaïck Détivaud,Christelle Haziza-Pigeon,Patricia Leroyer,Pierre Brissot,Olivier Loréal +6 more
TL;DR: It is demonstrated that Cyclin D1, a protein involved in G1-phase of cell cycle, is overexpressed in the iron-overloaded liver, suggesting a role of CyclIn D1 in iron-related hepatocarcinogenesis.
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