Denise Glaise
University of Rennes
64 Papers
942 Citations
Denise Glaise is an academic researcher from University of Rennes. The author has contributed to research in topics: Hepatocyte & Cell culture. The author has an hindex of 34, co-authored 64 publications. Previous affiliations of Denise Glaise include French Institute of Health and Medical Research & Vrije Universiteit Brussel.
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Papers
Infection of a human hepatoma cell line by hepatitis B virus
Philippe Gripon,Sylvie Rumin,Stephan Urban,Jacques Le Seyec,Denise Glaise,Isabelle Cannie,Claire Guyomard,Josette Lucas,Christian Trepo,Christiane Guguen-Guillouzo +9 more
TL;DR: A cell line, called HepaRG, is described, which exhibits hepatocyte-like morphology, expresses specific hepatocyte functions, and supports HBV infection as well as primary cultures of normal human hepatocytes, suitable for many applications including drug metabolism studies.
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma heparg cells
Caroline Aninat,Amélie Piton,Denise Glaise,Typhen Le Charpentier,Sophie Langouët,Fabrice Morel,Christiane Guguen-Guillouzo,André Guillouzo +7 more
TL;DR: HepaRG cells constitute the first human hepatoma cell line expressing high levels of the major P450s involved in xenobiotic metabolism and represent a reliable surrogate to human hepatocytes for drug metabolism and toxicity studies.
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The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
André Guillouzo,Anne Corlu,Caroline Aninat,Denise Glaise,Fabrice Morel,Christiane Guguen-Guillouzo +5 more
TL;DR: Recent results obtained with a new human hepatoma cell line, named HepaRG, derived from a human hepatocellular carcinoma, which could represent a surrogate to primary human hepatocytes for xenobiotic metabolism and toxicity studies and even more, a unique model system for analysing genotoxic compounds.
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Transdifferentiation of hepatocyte‐like cells from the human hepatoma HepaRG cell line through bipotent progenitor
Virginie Cerec,Denise Glaise,Denise Glaise,Delphine Garnier,Delphine Garnier,Serban Morosan,Serban Morosan,Serban Morosan,Bruno Turlin,Bruno Turlin,Bernard Drenou,Philippe Gripon,Philippe Gripon,Dina Kremsdorf,Dina Kremsdorf,Dina Kremsdorf,Christiane Guguen-Guillouzo,Christiane Guguen-Guillouzo,Anne Corlu,Anne Corlu +19 more
TL;DR: The results demonstrate the great plasticity of transformed hepatic progenitor cells and suggest that the transdifferentiation process could supply the pool of hepaticprogenitor cells, and highlight possible mechanisms by which trans Differentiation and proliferation of unipotent hepatocytes might cooperate in the development of mixed and differentiated tumors.
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The Mitogen-Activated Protein Kinase Kinase/Extracellular Signal- Regulated Kinase Cascade Activation Is a Key Signalling Pathway Involved in the Regulation of G 1 Phase Progression in Proliferating Hepatocytes
Hélène Talarmin,Claude Rescan,Sandrine Cariou,Denise Glaise,Giuliana Zanninelli,Marc Bilodeau,Pascal Loyer,Christiane Guguen-Guillouzo,Georges Baffet +8 more
TL;DR: Results show that early induction of the MEK/ERK cascade is restricted to hepatocytes from hepatectomized animals, allowing an early distinction of primed hepatocyte from those returning to quiescence, and argue for a crucial role of theMEK/ ERK cascade signalling pathway.
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