Angus C. Nairn
Yale University
509 Papers
7.9K Citations
Angus C. Nairn is an academic researcher from Yale University. The author has contributed to research in topics: Phosphorylation & Protein kinase A. The author has an hindex of 118, co-authored 469 publications. Previous affiliations of Angus C. Nairn include École Normale Supérieure & University of Missouri.
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Papers
Regulation of NMDA receptor trafficking by amyloid-beta.
Eric M. Snyder,Yi Nong,Claudia G. Almeida,Surojit Paul,Timothy D. Moran,Eun Young Choi,Angus C. Nairn,Angus C. Nairn,Michael W. Salter,Paul J. Lombroso,Gunnar K. Gouras,Paul Greengard +11 more
TL;DR: It is found that application of amyloid-β promoted endocytosis of NMDA receptors in cortical neurons, indicating a new mechanism by which amyloids-β can cause synaptic dysfunction and contribute to Alzheimer disease pathology.
1.5K
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.
John H. Hartwig,Marcus Thelen,Marcus Thelen,A. Resen,Paul A. Janmey,Angus C. Nairn,Alan Aderem +6 more
TL;DR: Modulation of the actin crosslinking activity of the MARCKS protein by calmodulin and phosphorylation represents a potential convergence of the calcium–calmodulinand PKC signal transduction pathways in the regulation of theActin cytoskeleton.
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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
Emmanuel Valjent,Vincent Pascoli,Per Svenningsson,Surojit Paul,Hervé Enslen,Jean-Christophe Corvol,Alexandre Stipanovich,Jocelyne Caboche,Paul J. Lombroso,Angus C. Nairn,Paul Greengard,Denis Hervé,Jean-Antoine Girault +12 more
TL;DR: Activation of ERK, by a multilevel protein phosphatase-controlled mechanism, functions as a detector of coincidence of dopamine and glutamate signals converging on medium-size striatal neurons and is critical for long-lasting effects of drugs of abuse.
650
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Julian C. Braz,Kimberly N. Gregory,Anand Pathak,Wen Zhao,Bogachan Sahin,Raisa Klevitsky,Thomas F. Kimball,John N. Lorenz,Angus C. Nairn,Stephen B. Liggett,Ilona Bodi,Su Wang,Arnold Schwartz,Edward G. Lakatta,Anna A. DePaoli-Roach,Jeffrey Robbins,Timothy E. Hewett,James A. Bibb,Margaret V. Westfall,Evangelia G. Kranias,Jeffery D. Molkentin +20 more
TL;DR: KC-α functions as a nodal integrator of cardiac contractility by sensing intracellular Ca2+ and signal transduction events, which can profoundly affect propensity toward heart failure.
617
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
James A. Bibb,Gretchen L. Snyder,Akinori Nishi,Zhen Yan,Laurent Meijer,Allen A. Fienberg,Li-Huei Tsai,Young T. Kwon,Jean-Antoine Girault,Andrew J. Czernik,Richard L. Huganir,Hugh C. Hemmings,Angus C. Nairn,Paul Greengard +13 more
TL;DR: Dopamine and cyclic AMP-regulated phospho-protein DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and aserine/Threonine phosphatase.
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