Paul A. Janmey
University of Pennsylvania
508 Papers
5.7K Citations
Paul A. Janmey is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gelsolin & Actin. The author has an hindex of 109, co-authored 473 publications. Previous affiliations of Paul A. Janmey include University of Geneva & Boston University.
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Papers
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Tony Yeung,Penelope C. Georges,Lisa A. Flanagan,Beatrice Marg,Miguelina Ortiz,Makoto Funaki,Nastaran Zahir,Wenyu Ming,Valerie M. Weaver,Paul A. Janmey,Paul A. Janmey +10 more
TL;DR: The hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands, is supported.
Nonlinear elasticity in biological gels.
Cornelis Storm,Cornelis Storm,Jennifer J. Pastore,Fred C. MacKintosh,Tom C. Lubensky,Paul A. Janmey +5 more
TL;DR: A molecular theory that accounts for strain-stiffening in a range of molecularly distinct gels formed from cytoskeletal and extracellular proteins and that reveals universal stress–strain relations at low to intermediate strains is reported.
1.6K
Effects of extracellular matrix viscoelasticity on cellular behaviour.
TL;DR: The role of viscoelasticity of tissues and extracellular matrices in cell–matrix interactions and mechanotransduction and the potential utility of vis coelastic biomaterials in regenerative medicine are explored.
1.4K
Elasticity of semiflexible biopolymer networks.
Fred C. MacKintosh,Fred C. MacKintosh,Josef A. Käs,Josef A. Käs,Paul A. Janmey,Paul A. Janmey +5 more
TL;DR: This model can explain a number of elastic properties of cross-linked gels and sterically entangled solutions of semiflexible biopolymers such as F-actin in vitro, including the concentration dependence of the storage modulus and yield strain.