Topic
Transitional Cell
About: Transitional Cell is a research topic. Over the lifetime, 336 publications have been published within this topic receiving 8723 citations.
Papers published on a yearly basis
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Papers
TL;DR: Thirteen rabbit atrioventricular nodes were studied both morphologically and electrophysiologically and two of these nodes were subsequently reconstructed in three-dimensional fashion.
Abstract: Thirteen rabbit atrioventricular nodes were studied both morphologically and electrophysiologically. Two of these nodes were subsequently reconstructed in three-dimensional fashion. From the morphological standpoint, it was shown that the atrioventricular node was divided into a smaller enclosed portion and a larger open portion by a fibrous collar derived from the central fibrous body. Three distinct nodal cell types were identified within these nodal segments. The open node was mostly occupied by transitional cells which merged proximally with the atrial myocardium. As they entered the enclosed node, some of these transitional cells merged into a knot of midnodal cells. Others passed circumferentially round this knot and together with the midnodal cells, joined with a tract of lower nodal cells. The latter cells were continuous with the His bundle anteriorly, but they also extended into the open node posteriorly. It was possible to correlate the activation sequence of the node accurately with the disposition of these cells. Using both reconstructions and techniques to mark cells from which action potentials had been recorded, it was shown that the transitional cells correlated with the AN zone of the node. Cells with N potentials were located in the environs of the midnodal cell knot. The anterior portion of the lower nodal cells correlated with the NH nodal zone. The posterior extension of the lower nodal cells and the overlay fibers of the anterior transitional cells both functioned as dead-end pathways. Histologically distinct tracts were not identified within the internodal atrial myocardium.
TL;DR: A quantitative difference in the extent and distribution of specialized intercellular junctions may be one of the factors responsible for the slow velocity of conduction characteristic of the Purkinje-ventricular junctional region.
Abstract: Cardiac cells with distinctive electrophysiological and morphological features were found at the junctional region between Purkinje and ventricular cells of the dog heart. The electrophysiological exploration of these "transitional" cells revealed action potentials markedly different in configuration from those generated by Purkinje or by ventricular cells. The impaled cardiac cells which generated transitional action potentials were identified in serial sections and studied with the light and the electron microscopes. The transitional cells were found to be characterized cytologically by: (a) their subendocardial location, (b) their small diameter, (c) the absence of T system and sarcoplasmic reticulum, and (d) the lack of intercalated discs under the light microscope and the sparsity of specialized intercellular junctions under the electron microscope. Purkinje, transitional, and ventricular cells were found to be joined by gap junctions permeable to lanthanum. A quantitative difference in the extent and distribution of specialized intercellular junctions may be one of the factors responsible for the slow velocity of conduction characteristic of the Purkinje-ventricular junctional region.
TL;DR: Results suggest that side population cells from the human bladder transitional cell cancer cell line T24 harbour stem-like cells.
Abstract: Cancer stem cells can be isolated from human tumours using specific cell surface markers. Bladder cancer cells, however, lack specific cell surface markers, making this approach impracticable. In this study an alternative method was used, involving isolation of side population cells to explore the stem cell characteristics of bladder cancer. Side population cells were isolated from the bladder transitional cell cancer cell line T24 and examined for potential stem cell characteristics related to proliferation, cell cycle distribution, self-renewal and differentiation. It was observed that T24 side population cells have stronger proliferative and colony formation abilities than non-side population cells. Side population cells were also more resistant to chemotherapy and radiotherapy, which may be due to expression of the ATP-binding cassette half-transporter, sub-family G, member 2 protein. Overall, the results suggest that side population cells from the human bladder transitional cell cancer cell line T24 harbour stem-like cells.
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 2 |
| 2021 | 4 |
| 2020 | 2 |
| 2019 | 3 |
| 2018 | 1 |
| 2015 | 3 |