TL;DR: This study illustrates the application of experimental design and multivariate data analysis in defining design space for granulation and tableting processes, and various control strategies that are based on the process understanding and assure desired quality attributes of the product are proposed.
TL;DR: HME is a robust process throughout the experimental design space for obtaining amorphous glassy solutions and for tabletting of such formulations since only minimal impact of the process parameters was detected on the extrudate and tablet properties.
TL;DR: In this article, a method was described for studying the behavior of homogeneous total mixes in different vibration conditions and three different total mixes were formed using direct compression tableting excipients and a model drug, potassium chloride.
TL;DR: Surface and structural characterization of tablets formulated with commonly used excipients pressed under different compaction conditions indicate that Mg stearate affects the particle-particle bonding and thus elastic recovery.
TL;DR: In this article, the relationship between the mechanical properties of single feed particles (< 100 µm) and their compaction behavior in order to produce tablets at low compression pressure with acceptable strength was investigated.