Topic
Tableting
About: Tableting is a research topic. Over the lifetime, 2049 publications have been published within this topic receiving 25749 citations.
Papers published on a yearly basis
1 / 2
Papers
Patent•
6 Oct 1994TL;DR: A tablet containing enteric granules prepared by tableting a mixture of granules containing a basis with at least one member selected from the group consisting of synthetic hydrotalcite, dried aluminum hydroxide gel, a coprecipitate of aluminum hydride with sodium hydrogen carbonate, aluminum magnesium hydroxides, synthetic aluminum silicate and dihydroxyaluminum aminoacetate is presented in this article.
Abstract: A tablet containing enteric granules prepared by tableting a mixture of enteric granules containing a basis with at least one member selected from the group consisting of synthetic hydrotalcite, dried aluminum hydroxide gel, a coprecipitate of aluminum hydroxide with sodium hydrogencarbonate, aluminum magnesium hydroxide, synthetic aluminum silicate and dihydroxyaluminum aminoacetate. As compared with the conventional tablets containing coated granules, this tablet has the following advantages: the content of enteric granules is increased by using a specified filler; the basis is rapidly dispersed in the granules; the granules have drug-release ability and acid resistance comparable to those before tableting; damage to the coating is reduced; weight variation during tableting is reduced; and the tablet has a high strength. The technique of preparing a tablet having a high enteric granule content has merits of an improved administrability due to a reduced size of the tablet and the applicability to other drugs.
13 citations
TL;DR: Improved mechanical behavior upon adsorption led to well-composed tablets that performed satisfactorily in vitro upon addition of a superdisintegrant, providing an insight on excipient-oriented rational development of solid SEDDS.
Abstract: FDA-approved self-emulsifying medicines rely on liquid-based formulations, which can exhibit limited stability and short shelf-lives Solid self-emulsifying drug delivery systems (SEDDS) can improve such issues, but there is still a great need for identifying suitable porous carriers to convert liquid SEDDS into solids without impairing their mechanical properties, functionality, and industrial feasibility The impact of SEDDS adsorption on tableting is also poorly understood Therefore, solid SEDDS were prepared by adsorbing liquid SEDDS onto ten commercially available porous excipients Products were assessed with respect to mechanical behavior, tabletability, and product performance Adsorbing SEDDS onto porous excipients led to satisfactory stability, with the exception of Zeopharm® 600 due to its high alkalinity, and Neusilin® US2/UFL2, which caused quercetin to crystallize out of the liquid concentrate SEDDS adsorption reduced the elastic recovery of most excipients, making tableting achievable using Aeroperl® 300 and Aerosil® 200/300 The impact of SEDDS on elastic recovery provides additional understanding on solid SEDDS manufacture process Acceptable tablets were made via direct compression but with slow disintegration Addition of a superdisintegrant (crospovidone 5% w/w) ensured tablet manufacturing without impairment of product performance Solid SEDDS displayed several technical advantages over their liquid counterparts, but attention must be given to the properties of the porous excipient chosen Drug-excipient interactions play a significant role in drug degradation and crystallization in solid SEDDS Improved mechanical behavior upon adsorption led to well-composed tablets that performed satisfactorily in vitro upon addition of a superdisintegrant This study provides an insight on excipient-oriented rational development of solid SEDDS
13 citations
Journal Article•
TL;DR: This paper evaluated tamarind seed polyose as a binder for tablet dosage forms for the wet granulation as well as direct compression methods and found that it is a suitable polymer for sustained release formulations of low drug loading.
Abstract: Evaluation of tamarind seed polyose as a binder for tablet dosage forms was taken up for the wet granulation as well as direct compression methods. The drug release sustaining properties of tamarind seed polyose polymer were also studied using 5 mg of terbutaline sulphate matrices. The results indicated that tamarind seed polyose could be used as binder for wet granulation and direct compression tableting methods as well as a suitable polymer for sustained release formulations of low drug loading.
13 citations
Patent•
24 Jan 2006
TL;DR: In this article, a new composition of candesartan cilexetil is prepared using up to 20% of carrageenan which suitably stabilized the active ingredient against degradation during the tableting.
Abstract: New composition of candesartan cilexetil is prepared using up to 20% of carrageenan which suitably stabilized the active ingredient against degradation during the tableting
13 citations
Patent•
10 Jun 1968
TL;DR: In this paper, the authors present a method and means for monitoring a multistation tableting machine with respect to the forces applied by tablet-forming punch means to tablets successively formed in and ejected from said machine.
Abstract: Method and means for monitoring a multistation tableting machine with respect to the forces applied by tablet-forming punch means to tablets successively formed in and ejected from said machine which comprises continuously measuring the electric power requirement of said machine with respect to predetermined overload and underload norms of operation.
13 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 16 |
| 2024 | 43 |
| 2023 | 60 |
| 2022 | 105 |
| 2021 | 59 |
| 2020 | 96 |