TL;DR: To analyze the joint action of two (or more) insecticides, the actual toxicity indexes of the components and their mixture are determined by dosage-mortality curves, and a mixture of methyl parathion and sesamex indicated significant antagonism.
Abstract: To analyze the joint action of two (or more) insecticides, the actual toxicity indexes of the components and their mixture are determined by dosage-mortality curves. The theoretical toxicity of the same mixture is equal to the sum of toxicity indexes calculated from the percentage of each component times its respective toxicity index. Therefore, the joint toxicity or Co-toxicity coefficient of a mixture A coefficient of a mixture near 100 indicates probability of similar action; independent action usually should give a coefficient less than 100, while a coefficient significantly above 100 strongly indicates synergism. Toxicity significantly less than that of the strongest toxicant alone shows antagonism.
Thirty-nine mixtures each containing two to four insecticides were tested against the house fly ( Musca domestica L.) and their results were calculated by this method. Generally, chemically related compounds gave similar action, while unrelated compounds gave independent action. 3-(Dimethoxyphosphinyloxy)-N,N-dimethyl-crotonamide (SD 3562)and sesamex showed high synergistic action. However, a mixture of methyl parathion and sesamex indicated significant antagonism.
TL;DR: Inhibition of the enzyme by carbon monoxide, ionic detergents, sulfhydryl reagents, chelating agents and electron acceptors, together with the demonstrated presence of a b 5 cytochrome and an active NADPH-cytochrome c reductase are discussed as indirect evidence for a microsomal electron transport system in plants similar to those reported for animals.
TL;DR: Four resistance factors were isolated genetically from the NPR strain of houseflies (Musca domestica L.), which resists natural pyrethrins, and were characterised toxicologically.
Abstract: Four resistance factors were isolated genetically from the NPR strain of houseflies (Musca domestica L.), which resists natural pyrethrins, and were characterised toxicologically. The four factors were : pen, which reduces the rate of penetration of insecticides through the cuticle; kdr-NPR, a general pyrethroid resistance mechanism unaffected by the synergist sesamex; py-ses, a mechanism of resistance to natural pyrethrins that can be suppressed by sesamex; and py-ex, a factor that gives strong resistance to synergised natural pyrethrins and to the new synthetic esters, e.g. resmethrin, but little or none to natural pyrethrins alone.
TL;DR: The metabolism of twenty-five N:N-dimethyl carbamates and twenty-three related compounds was investigated and isolan metabolism was evident when followed both by the formation of formaldehyde-yielding material and reduction in the ability to inhibit cholinesterase in vitro.
TL;DR: Housefly (Musca vicina) microsomes contain a system which converts aldrin to dieldrin and which requires the presence of NADPH and O2, which is stimulated by cyanide and inhibited by EDTA, sesamex and carbon monoxide.