TL;DR: It is concluded that absence of the pericardium results in echocardiographic abnormalities which mimic those seen in right ventricular volume overload which may be due to altered cardiac position and motion within the thorax resulting from loss of normalPericardial restraint.
Abstract: The purpose of this study was to investigate the echocardiographic effects of absence of the pericardium Five patients with congenital complete absence of the left pericardium were studied All had typical chest X-rays, four had cardiac catheterization which excluded any intracardiac shunts, and one had diagnostic pneumothorax All five had an enlarged right ventricular dimension (RVD): 19 +/- 01 cm/m2 (normal: less than 13 cm/m2) and abnormal interventricular septal (IVS) motion (three Type A, two Type B) Sixteen additional patients were studied after pericardial stripping for a variety of conditions In none was cardiopulmonary bypass used Eight of these patients had preoperative echocardiograms; all showed normal IVS motion After surgery RVD was large in all 16 patients, increasing from 10 +/- 02 cm/m2 preoperatively to 17 +/- 01 cm/m2 postoperatively, P less than 001 Fourteen of the 16 patients had abnormal IVS motion, nine Type A, and five Type B We conclude that absence of the pericardium results in echocardiographic abnormalities which mimic those seen in right ventricular volume overload This may be due to altered cardiac position and motion within the thorax resulting from loss of normal pericardial restraint
TL;DR: Twenty-three of 37 patients with adequate clinical information were reported to have had a diagnosis of postpericardiotomy syndrome after the original surgery, and three patients had more extensive pericardial stripping and showed clinical improvement.
TL;DR: A patient who developed life-threatening constrictive pericarditis 8 weeks after high-dose chemotherapy is described, which the clinician should be alerted to this potential complication of high- dose chemotherapy.
TL;DR: A 77‐year‐old male patient with 1‐year history of progressive dyspnea on exertion, and lower extremity edema was admitted to the authors' institution and diagnosed as idiopathic constrictive pericarditis.
Abstract: A 77-year-old male patient was admitted to our institution with 1-year history of progressive dyspnea on exertion, and lower extremity edema. His chest x-ray showed a circumferential pericardial calcification and right-sided pleural effusion. The electrocardiography revealed atrial fibrillation with low voltage in all derivations and diffuse nonspecific T-wave inversions. The transesophageal echocardiography showed a thickened pericardium with biatrial enlargement and normal right and left ventricular systolic functions. A thick echogenic structure that caused impression and narrowing of the ascending aorta was observed. Simultaneous right and left heart catheterization showed elevation and equalization of right-sided and left-sided diastolic filling pressures, with characteristic dip and plateau. Aortic angiogram showed the ascending aorta was impressed and narrowed by calcified pericardium. Cine magnetic resonance imaging showed pericardial calcifications impressing and narrowing of the ascending aorta. All these findings were consistent with constrictive pericarditis. The patient had no history of tuberculosis, cardiac surgery, or mediastinal irradiation. His HIV antibody test was negative. Marked pericardial thickening and calcifications were evident during pericardiectomy. Histological analysis of the pericardium showed dense collageneous matrix, mild chronic inflammation and calcification. The culture of pericardial tissue revealed no identifiable cause including tuberculosis. The patient was diagnosed as idiopathic constrictive pericarditis. The patient's symptoms and edema decreased remarkably after pericardial stripping. He remained well at 1-year follow-up.
TL;DR: 2 patients with ECP who were managed successfully with steroids and colchicine, respectively, thus obviating the need for surgery are described, and the current understanding of this reversible pericardial pathology is reviewed.
Abstract: Effusive constrictive pericarditis (ECP) is a relatively infrequent pericardial condition. The diagnosis is typically made when symptoms and right heart pressure elevation persist despite drainage of pericardial effusion. Visceral and parietal pericardial stripping is an extensive procedure with significant morbidity and mortality but is widely considered the only effective treatment. Recent studies suggest that up to 10% of constriction may be reversible, and a newer series has reported spontaneous complete resolution of symptoms in a subset of ECP patients. In this review, the authors describe 2 patients with ECP who were managed successfully with steroids and colchicine, respectively, thus obviating the need for surgery. The authors also review the current understanding of this reversible pericardial pathology and explore the possible role for colchicine in treating this condition.