About: Monkeypox is a research topic. Over the lifetime, 479 publications have been published within this topic receiving 15931 citations. The topic is also known as: infections, Monkeypox virus & Monkeypox virus infection.
TL;DR: Sera of persons examined within 10 years after vaccination showed similar results with IF and N, with the median titre of IF decreased from 512 in the most recently vaccinated group to 32 in the group which was vaccinated ≥51 years previously.
Abstract: A collection of 408 human sera and 165 monkey sera were examined for vaccinia and monkeypox antibodies respectively by immunofluorescence (IF). Neutralization (N) was performed for comparison in 266 of the human and all monkey sera.
TL;DR: In this article , the authors summarize some information about this virus and its re-emergence and the current vaccines that are proposed to limit its spread and present some possible avenues for developing new vaccines.
TL;DR: Results indicate that the mechanism of how antibodies against A33 and B5 protect differ, and show the complexity of designing optimized vaccine-formulations containing multiple adjuvants and recombinant protein-based antigens.
TL;DR: It is thought that this agent, temporarily called ‘1211’, is a new unclassified poxvirus which is infectious for primates and may be the same as that recently reported from Texas2.
Abstract: PRIMATES are susceptible to poxviruses of the variola–vaccinia–monkeypox group and to Yaba poxvirus. When an epidemic of skin lesions with the clinical characteristics of vaccinia appeared in rhesus monkeys (Macaca mulatta), Japanese macaques (Macaca fuscata) and animal personnel in our colony, monkeypox was suspected. Electron micrographs of biopsied skin lesions showed particles resembling poxvirus1,2. The agent, subsequently isolated in tissue cultures, is, however, morphologically and serologically distinct from the vaccinia group, and the histopathology is totally different from that of Yaba virus. We therefore think that this agent, temporarily called ‘1211’, is a new unclassified poxvirus which is infectious for primates and may be the same as that recently reported from Texas2.
TL;DR: In this article , the authors reported clinical features and outcome of human Mpox of the first cases in Saudi Arabia, which was mild to moderate, did not require antiviral medications, and lasted 7-15 days.