TL;DR: Heteropoly acid H3PW12O40 supported on silica (PW/SiO2) has been used as an effective catalytic system for a four-component coupling process for the synthesis of β-acetamido ketones by Dakin-West reaction as mentioned in this paper.
Abstract: Heteropoly acid H3PW12O40 (PW) supported on silica (PW/SiO2) has been used as an effective catalytic system for a four-component coupling process for the synthesis of β-acetamido ketones by Dakin–West reaction. The present methodology offers several advantages, such as high yields, short reaction times, mild condition and a recyclable catalyst with a very easy work up.
TL;DR: In this paper, a tripeptide containing a ketomethylene isostere was synthesized for the first time in Fmoc chemistry by using a modified Dakin-West reaction.
TL;DR: An efficient improved procedure for the synthesis of beta-acetamido ketones has been developed by a heteropoly acid (HPA) catalyzed three-component coupling protocol that offers several advantages such as excellent yields, simple procedure, short reaction times, and mild conditions.