TL;DR: In the subgroup analysis of singleton gestations with short cervical length, especially those with a prior pre term birth, cerclage may reduce preterm birth, and a well-powered trial should be carried out in this group of patients.
TL;DR: In this article, a meta-analysis of randomized trials was performed to estimate if cerclage prevents preterm birth and perinatal mortality and morbidity in women with previous preterm births, singleton gestation, and short cervical length.
TL;DR: The patient was admitted to hospital on 3rd February, 1952, complaining of low backache and a mucous discharge, and when speculum examination revealed cervical dilatation, no suture was inserted and she was delivered normally of a male child weighing 6 pounds 4 ounces.
TL;DR: In women with a prior spontaneous preterm birth less than 34 weeks and cervical length less than 25 mm, cerclage reduced previable birth and perinatal mortality but did not prevent birth more than 35 weeks, unless cervical length was less than 15 mm.
TL;DR: Women with CIN have a higher baseline risk for prematurity and excisional and ablative treatment further increases that risk, and the frequency and severity of adverse sequelae increases with increasing cone depth and is higher for excision than for ablation.
Abstract: Objective To assess the effect of treatment for cervical intraepithelial neoplasia (CIN) on obstetric outcomes and to correlate this with cone depth and comparison group used. Design Systematic review and meta-analysis. Data sources CENTRAL, Medline, Embase from 1948 to April 2016 were searched for studies assessing obstetric outcomes in women with or without previous local cervical treatment. Data extraction and synthesis Independent reviewers extracted the data and performed quality assessment using the Newcastle-Ottawa criteria. Studies were classified according to method and obstetric endpoint. Pooled risk ratios were calculated with a random effect model and inverse variance. Heterogeneity between studies was assessed with I2 statistics. Main outcome measures Obstetric outcomes comprised preterm birth (including spontaneous and threatened), premature rupture of the membranes, chorioamnionitis, mode of delivery, length of labour, induction of delivery, oxytocin use, haemorrhage, analgesia, cervical cerclage, and cervical stenosis. Neonatal outcomes comprised low birth weight, admission to neonatal intensive care, stillbirth, APGAR scores, and perinatal mortality. Results 71 studies were included (6 338 982 participants: 65 082 treated/6 292 563 untreated). Treatment significantly increased the risk of overall ( Conclusions Women with CIN have a higher baseline risk for prematurity. Excisional and ablative treatment further increases that risk. The frequency and severity of adverse sequelae increases with increasing cone depth and is higher for excision than for ablation.