Journal Article10.1007/S10765-017-2323-6
Solubility Determination and Modeling and Dissolution Thermodynamic Properties of Raspberry Ketone in Binary Solvent Mixtures of Ethanol and Water
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TL;DR: In this paper, the van-t Hoff, modified Apelblat and 3D Jouyban-Acree-van't Hoff equations were increasingly applied to correlate the solubility in ethanol/water binary solvent mixtures.
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Abstract: The solubility and dissolution thermodynamic properties of raspberry ketone in a set of binary solvent mixtures (ethanol + water) with different compositions were experimentally determined by static gravimetrical method in the temperature range of 283.15–313.15 K at 0.10 MPa. The solubility of raspberry ketone in this series of ethanol/water binary solvent mixtures was found to increase with a rise in temperature and the rising mole fraction of ethanol in binary solvent mixtures. The van’t Hoff, modified Apelblat and 3D Jouyban–Acree–van’t Hoff equations were increasingly applied to correlate the solubility in ethanol/water binary solvent mixtures. The former two models could reach better fitting results with the solubility data, while the 3D model can be comprehensively used to estimate the solubility data in all the ratios of ethanol and water in binary solvent mixtures at random temperature. Furthermore, the changes of dissolution thermodynamic properties of raspberry ketone in experimental ethanol/water solvent mixtures were obtained by van’t Hoff equation. For all the above experiments, these dissolution processes of raspberry ketone in experimental ethanol/water binary solvent mixtures were estimated to be endothermic and enthalpy-driven.
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Citations
Phase Transition Enthalpy Measurements of Organic Compounds. An Update of Sublimation, Vaporization, and Fusion Enthalpies from 2016 to 2021
TL;DR: The compendium of phase change enthalpies published in two parts in 2016 is updated to include new fusion, vaporization, and sublimation enthalps published in the interim and includes some earlier data either previously missed or were unavailable as discussed by the authors .
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Advances in the synthesis and applications of raspberry ketone: A review
TL;DR: The recent advances in the synthesis and applications of raspberry ketone are reviewed in this paper, where different methods, including chemical synthesis, biotechnological methods, and extraction, are compared, and the applications of Raspberry ketone in flavour and fragrance, medicinal chemistry and tobacco manufacture are also discussed.
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Solubility and thermodynamic properties of N-acetylglucosamine in mono-solvents and binary solvents at different temperatures
TL;DR: The solubility data of N-acetylglucosamine in five pure solvents (water, methanol, ethanol, n-propanol and acetone) and two binary (water+ethanol, water+acetone) were measured by gravi...
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Solubility Correlation by Model with Partial Molar Volume
TL;DR: In this article , the partial molar volume of each component in the mixture of two solvents was first time introduced as a modification to the Jouyban-Acree/van't Hoff model.
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Raspberry ketone loaded self nanoemulsifying system of cardamom oil: Assessment of phase behaviour, dissolution rate and anti-hyperlipidemic activity
Anoop Kumar,Kumari Shipam,Shobhit Kumar +2 more
TL;DR: Raspberry ketone-loaded self-nanoemulsifying system of cardamom oil enhances RK dissolution and anti-hyperlipidemic activity, with optimized formulation F3 showing significant reduction in lipid markers and improved stability for six months at 30±2°C; 65±5 % RH conditions.
References
Microbial production of natural raspberry ketone
Jules Beekwilder,Ingrid M. van der Meer,Ole Sibbesen,Mans Broekgaarden,Ingmar Qvist,Joern Dalgaard Mikkelsen,Robert Hall +6 more
TL;DR: Conditions have been determined that result in significant levels of raspberry ketone, up to 5 mg/L, and these results lay a strong foundation for a potentially renewable source of "natural" flavour compounds making use of plant genes.
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Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits
TL;DR: It is concluded that RZS1 is responsible for hydrogenation of the α,β-unsaturated double bond of phenylbutenones, the final step of the raspberry ketone biosynthesis, in the raspberry fruits.
58
Determination and correlation of solubility and thermodynamic properties of pyraclostrobin in pure and binary solvents
TL;DR: In this article, the solubility of pyraclostrobin in five pure solvents and two binary solvent mixtures was measured from 283.15 K to 308.15K using a static analytical method.
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Raspberry ketone in food supplements – High intake, few toxicity data – A cause for safety concern?
Lea Bredsdorff,Eva Bay Wedebye,Nikolai Georgiev Nikolov,Torben Hallas-Møller,Kirsten Pilegaard +4 more
TL;DR: Investigations of raspberry ketone in quantitative structure-activity relationship (QSAR) models indicated potential cardiotoxic effects and potential effects on reproduction/development and the compound's toxic potential should be clarified with further experimental studies.
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Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.
TL;DR: RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons isolated from wild-type (WT) mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation.
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