Reproductive Decision Making and Genetic Predisposition to Sudden Cardiac Death
TL;DR: The “disability critique” of prenatal testing should be applied carefully to the context of genetic predisposition to sudden cardiac death in order to understand reproductive decision making.
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Abstract: Background: With current genetic technology, it is possible to detect mutations associated with long QT syndrome (LQTS), a hereditary cardiac arrhythmia syndrome. As a result, prospective parents diagnosed with LQTS will have to decide whether or not to prevent its transmission to future generations, either by not procreating or through the use of assisted reproductive technologies or prenatal testing. This article explores how a hereditary predisposition to sudden cardiac death can influence reproductive decision making. Methods: This study draws from interviews and focus groups with individuals who have personal or family histories of cardiac arrhythmia or sudden death. A keyword search was conducted on interview transcripts to identify quotes for analysis. Results: Participants expressed complex, often ambivalent attitudes about the prospect of having a child with a predisposition to sudden cardiac death. Their comments reveal conflicting understandings of genetic responsibility and reflect the variabl...
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Psychological stress associated with cardiogenetic conditions
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Prenatal diagnosis and selective abortion: a challenge to practice and policy.
TL;DR: It is suggested that unreflective uses of prenatal testing could diminish, rather than expand, women's choices, and the conviction that women will or should end their pregnancies if they discover that the fetus has a disabling trait is challenged.