Journal Article10.1053/J.ACKD.2016.09.002
Protocol Biopsies: Utility and Limitations.
Yihung Huang,Evan A. Farkash +1 more
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TL;DR: In this paper, protocol biopsies are performed after reperfusion to establish baseline, between 3 and 6 months to identify subclinical rejection and at 6-12 months to assess chronicity and persistent inflammation that have prognostic implication.
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About: This article is published in Advances in Chronic Kidney Disease. The article was published on 01 Sep 2016. The article focuses on the topics: Transplant glomerulopathy & Subclinical infection.
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Citations
Kidney Allograft Fibrosis: Diagnostic and Therapeutic Strategies
TL;DR: This review discusses the role and origin of myofibroblasts as matrix producing cells and therapeutic targets in renal fibrosis with a particular focus on renal allografts and current trends to use multi-omic approaches to identify new biomarkers for IF/TA detection and to predict allografted survival.
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Two-Week Protocol Biopsy in Renal Allograft: Feasibility, Safety, and Outcomes
Manuel Lim,Byung Kwan Park,Kyo Won Lee,Jae H. Park,Kyeong Deok Kim,Jaehun Yang,Ji-Hye Kwon,Eun Sung Jeong,SeungGwan Lee +8 more
TL;DR: Two-week protocol biopsy is technically feasible and safe and contributes to early detecting a substantial number of SCRs, and platelet count and blood urea nitrogen should be carefully checked to predict major complications.
Clinical Significance of Renal Allograft Protocol Biopsies: A Single Tertiary Center Experience in Malaysia.
TL;DR: Despite having a stable renal function, adult recipients of kidney transplantation had a significant number of subclinical rejection on renal allograft biopsies, and living-related donor recipients were associated with decreased SCR.
Fine needle aspirates of kidneys: a promising tool for RNA sequencing in native and transplanted kidneys
Øystein Solberg Eikrem,Øystein Solberg Eikrem,Tedd Christian Walther,Arnar Flatberg,Vidar Beisvag,Philipp Strauss,Magnus Farstad,Christian Beisland,Christian Beisland,Even Koch,Thomas F. Mueller,Hans-Peter Marti,Hans-Peter Marti +12 more
TL;DR: The less invasive nature of fine needle biopsies may therefore permit more frequent molecular monitoring and a more targeted use of core needleBiopsies in native and especially in transplanted kidneys.
Post-Transplant Surveillance and Management of Chronic Active Antibody-Mediated Rejection in Renal Transplant Patients in Europe
Lionel Rostaing,Georg A. Böhmig +1 more
TL;DR: In this paper , a 15-minute online survey with 58 multiple choice or open-ended questions was completed by EU transplant nephrologists, transplant surgeons and nephologists.
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References
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary
Bertram L. Kasiske,Martin Zeier,Jeremy R. Chapman,Jonathan C. Craig,Henrik Ekberg,Catherine A. Garvey,Michael Green,Vivekanand Jha,Michelle A. Josephson,Bryce A. Kiberd,Henri Kreis,Ruth A. McDonald,John M. Newmann,Gregorio T. Obrador,Flavio Vincenti,Michael Cheung,Amy Earley,Gowri Raman,Samuel A Abariga,Martin Wagner,Ethan M Balk +20 more
TL;DR: The guideline makes recommendations for immunosuppression and graft monitoring, as well as prevention and treatment of infection, cardiovascular disease, malignancy, and other complications that are common in kidney transplant recipients, including hematological and bone disorders.
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The natural history of chronic allograft nephropathy.
Brian J. Nankivell,Richard Borrows,Caroline L.-S. Fung,Philip J. O'Connell,Richard D. M. Allen,Jeremy R. Chapman +5 more
TL;DR: Chronic allograft nephropathy represents cumulative and incremental damage to nephrons from time-dependent immunologic and nonimmunologic causes, and was irreversible, resulting in declining renal function and graft failure.
1.9K
Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions
Kim Solez,Robert B. Colvin,Lorraine C. Racusen,Mark Haas,Banu Sis,Michael Mengel,Philip F. Halloran,William M. Baldwin,G. Banfi,A. B. Collins,Fernando G. Cosio,D. S. R. David,Cinthia B. Drachenberg,Gunilla Einecke,Agnes B. Fogo,Ian W. Gibson,Denis Glotz,Samy S. Iskandar,Edward S. Kraus,Evelyne Lerut,Roslyn B. Mannon,Michael J. Mihatsch,Brian J. Nankivell,Volker Nickeleit,John C. Papadimitriou,Parmjeet Randhawa,Heinz Regele,Karine Renaudin,Ian S.D. Roberts,Daniel Serón,Rex Neal Smith,Marialuisa Valente +31 more
TL;DR: Emerging research data led to the establishment of collaborative working groups addressing issues like isolated ‘v’ lesion and incorporation of omics‐technologies, paving the way for future combination of graft biopsy and molecular parameters within the Banff process.
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Polyomavirus-Associated Nephropathy in Renal Transplantation: Interdisciplinary Analyses and Recommendations
Hans H. Hirsch,Daniel C. Brennan,Cinthia B. Drachenberg,Fabrizio Ginevri,Jennifer Gordon,Ajit P. Limaye,Michael J. Mihatsch,Volker Nickeleit,Emilia Ramos,Parmjeet Randhawa,Ron Shapiro,Juerg Steiger,Manikkam Suthanthiran,Jennifer Trofe +13 more
TL;DR: It is recommended that all renal transplant recipients should be screened for BKV replication in the urine every three months during the first two years posttransplant; and if PVAN and concurrent acute rejection is diagnosed, antirejection treatment should be considered, coupled with subsequently reducing immunosuppression.
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Evolution and Clinical Pathologic Correlations of De Novo Donor‐Specific HLA Antibody Post Kidney Transplant
Chris Wiebe,Ian W. Gibson,Tom Blydt-Hansen,Martin Karpinski,Julie Ho,Leroy Storsley,Aviva Goldberg,Patricia E. Birk,David N. Rush,Peter Nickerson +9 more
TL;DR: Pathology consistent with antibody‐mediated injury can occur and progress in patients with dnDSA in the absence of graft dysfunction and furthermore, nonadherence and cellular rejection contribute to dNDSA development and progression to graft loss.
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