Journal Article10.1002/btm2.10447
Peptide‐functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration
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TL;DR: In this article , a double network hydrogel was used to reconstruct intervertebral disc (IVD) degeneration from disc transplantation, which is a promising approach to IVD regeneration with other potential biomedical applications.
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Abstract: Abstract As a prominent approach to treat intervertebral disc (IVD) degeneration, disc transplantation still falls short to fully reconstruct and restore the function of native IVD. Here, we introduce an IVD scaffold consists of a cellulose‐alginate double network hydrogel‐based annulus fibrosus (AF) and a cellulose hydrogel‐based nucleus pulposus (NP). This scaffold mimics native IVD structure and controls the delivery of Growth Differentiation Factor‐5 (GDF‐5), which induces differentiation of endogenous mesenchymal stem cells (MSCs). In addition, this IVD scaffold has modifications on MSC homing peptide and RGD peptide which facilitate the recruitment of MSCs to injured area and enhances their cell adhesion property. The benefits of this double network hydrogel are high compressibility, shape memory effect, and mechanical strength comparable to native IVD. In vivo animal study demonstrates successful reconstruction of injured IVD including both AF and NP. These findings suggest that this double network hydrogel can serve as a promising approach to IVD regeneration with other potential biomedical applications.
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Citations
Peptide‐functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration
TL;DR: In this article , a double network hydrogel was used to reconstruct intervertebral disc (IVD) degeneration from disc transplantation, which is a promising approach to IVD regeneration with other potential biomedical applications.
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Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review
Yuheng Liu,Zhen Zhao,Chuan Guo,Zhangheng Huang,Weifei Zhang,Fei Ma,Zhe Wang,Qingquan Kong,Yu Wang +8 more
TL;DR: This review first briefly describes the anatomy, pathology, and current treatments of IVDD, and then introduces different types of hydrogels and addresses “smart hydrogel”.
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Immune-defensive microspheres promote regeneration of the nucleus pulposus by targeted entrapment of the inflammatory cascade during intervertebral disc degeneration
Liang Zhou,Feng Cai,Hongyi Zhu,Yichang Xu,Jincheng Tang,Wei Wang,Ziang Li,Jie Wu,Zhouye Ding,Kun Xi,Liang Chen +10 more
TL;DR: Researchers developed immunomodulatory microspheres that target and reduce inflammation in intervertebral disc degeneration, promoting nucleus pulposus regeneration by sustained release of TGF-β1 and inhibiting inflammatory factors, improving disc height and biomechanical function in a rat model.
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A new strategy for intervertebral disc regeneration: The synergistic potential of mesenchymal stem cells and their extracellular vesicles with hydrogel scaffolds.
Yan Zhao,Huaize Dong,Qiuqiu Xia,Yanyang Wang,Lu Zhu,Zongyue Hu,Jiyue Xia,Qiming Mao,Zijing Weng,Jiangbi Yi,Shuai Feng,Youhong Jiang,Wenbo Liao,Zhijun Xin +13 more
- 02 Feb 2024
TL;DR: The synergistic effects of MSCs and EVs in treating IDD in combination with hydrogels are outlined and theoretical references are provided to provide theoretical references for future related studies.
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Single Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis
Guanrui Huang,Haotian Shen,Kaiwang Xu,Yifan Shen,Jiale Jin,Guangyu Chu,Hongyuan Xing,Zhiyun Feng,Yue Wang +8 more
TL;DR: For the first time, microgel-encapsulated MSC was used to treat disc degeneration and obtain encouraging outcomes, and the developed biocompatible single-cell hydrogel is an effective strategy to protect MSC and maintain cellular functions and may be an efficacious approach to improving the efficacy of MSC therapy in treating disc degeneration.
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References
Magnetic resonance classification of lumbar intervertebral disc degeneration.
TL;DR: Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.
3.7K
What low back pain is and why we need to pay attention
Jan Hartvigsen,Mark J. Hancock,Alice Kongsted,Quinette Louw,Manuela L Ferreira,Stéphane Genevay,Damian G Hoy,Jaro Karppinen,Glenn Pransky,Joachim Sieper,Rob J. E. M. Smeets,Martin Underwood,Rachelle Buchbinder,Dan Cherkin,Nadine E. Foster,Christopher G. Maher,Maurits W. van Tulder,Johannes R. Anema,Roger Chou,Steven P. Cohen,Lucíola da Cunha Menezes Costa,Peter Croft,Manuela L. Ferreira,Paulo H. Ferreira,Julie M. Fritz,Douglas P. Gross,Bart W. Koes,Birgitta Öberg,Wilco C. Peul,Mark L. Schoene,Judith A. Turner,Anthony D. Woolf +31 more
TL;DR: Intensified research efforts and global initiatives are clearly needed to address the burden of low back pain as a public health problem, where health and other systems are often fragile and not equipped to cope with this growing burden.
3.6K
A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration.
Koichi Masuda,Yoichi Aota,Carol Muehleman,Yoshiyuki Imai,Masahiko Okuma,Eugene J.-M.A. Thonar,Gunnar B. Andersson,Howard S. An +7 more
TL;DR: The needle puncture approach, using 16G to 21G needles, resulted in a reproducible decrease of disc height and magnetic resonance imaging grade, which will benefit researchers studying disc degeneration.
704
The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain
TL;DR: In this review, those areas of biology that are currently influencing, or could conceivably soon impinge on, clinical thinking or practice around IVD degeneration and discogenic back pain are described and discussed.
505
High-Strength and High-Toughness Double-Cross-Linked Cellulose Hydrogels: A New Strategy Using Sequential Chemical and Physical Cross-Linking
TL;DR: The construction of double‐cross‐linked (DC) cellulose hydrogels is described using sequential chemical and physical cross‐linking, resulting in DC celluloseHydrogels that are mechanically superior to single‐ cross‐linked cellulosehydrogels.
483