Journal Article10.1016/J.LFS.2021.119864
Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications.
Praveen Kumar Issac,Ajay Guru,Manikandan Velayutham,Raman Pachaiappan,Mariadhas Valan Arasu,Naif Abdullah Al-Dhabi,Ki Choon Choi,Ramasamy Harikrishnan,Jesu Arockiaraj +8 more
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TL;DR: In this paper, the authors examined that morin as possible antioxidant and neuroprotective due to oxidative stress (H2O2) in zebrafish larval model and found that restoring antioxidant enzymes and reduced lipid peroxidation which had a neuro-protective impact.
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About: This article is published in Life Sciences. The article was published on 15 Oct 2021. The article focuses on the topics: Oxidative stress & Glutathione.
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Citations
Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae
TL;DR: The findings reveal butylparaben and propyl paraben as an anxiogenic neuroactive compound capable of inducing anxiety‐like behavior through a mechanism involving oxidative‐stress‐induced apoptosis in the head of zebrafish larvae, which suggests a potential hazard to the early life ofZebrafish and this can be extrapolated to human health as well.
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Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle.
B. Hari Deva Muthu,Tamilvelan Manjunathan,Ajay Guru,Rajendran Saravana Kumar,R. Rajakrishnan,Palaniselvam Kuppusamy,A Benitta juliet,Pushparathinam Gopinath,Jesu Arockiaraj +8 more
TL;DR: In this article , the free radical quenching ability of synthesized benzo[b]thiophene derivatives using in vitro assays and acrylamide induced oxidatively stressed model in zebrafish larvae was investigated.
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Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model
Gokul Sudhakaran,Pandurangan Prathap,Ajay Guru,B. Haridevamuthu,Raghul Murugan,Bader Almutairi,Mikhlid Almutairi,A Benitta juliet,Pushparathinam Gopinath,Jesu Arockiaraj +9 more
TL;DR: The study suggested that N2 could be an effective therapeutic agent for the treatment of ALD and other inflammatory conditions by downregulating the mRNA levels.
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Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model
Nagaram Prabha,Ajay Guru,Ramasamy Harikrishnan,Mansour K. Gatasheh,Ashraf A. Hatamleh,A. Hency Juliet,Jesu Arockiaraj +6 more
TL;DR: In this paper , the authors evaluated the neuroprotective and antioxidant ability of a short peptide, RW20 derived from histone acetyltransferases (HATs), using bioinformatics tools, the short amino acid sequence of RF13 peptide with antioxidant activity was predicted from HAT of Channa striatus transcriptome.
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Lipid-Lowering and Antioxidant Activity of RF13 Peptide From Vacuolar Protein Sorting-Associated Protein 26B (VPS26B) by Modulating Lipid Metabolism and Oxidative Stress in HFD Induced Obesity in Zebrafish Larvae
TL;DR: Results suggests that RF13 peptides can be used as functional foods and natural drugs to enhance the antioxidant ability and also to alleviate lipid accumulation by regulating lipid metabolism.
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