Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis.
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TL;DR: This is the first demonstration of increased expression of genes in the inositol biosynthetic pathway by both lithium and valproate, which has far-reaching implications for predicting genetic determinants of responsiveness and resistance to these agents.
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About: This article is published in Journal of Biological Chemistry. The article was published on 04 May 2001. and is currently open access. The article focuses on the topics: Inositol & Lithium (medication).
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Citations
Valproate disrupts regulation of inositol responsive genes and alters regulation of phospholipid biosynthesis
Shulin Ju,Miriam L. Greenberg +1 more
TL;DR: In contrast to the effect of chronic VPA treatment, short‐term exposure to VPA abrogated the normal response to inositol depletion of inositl responsive genes and led to aberrant synthesis of phospholipids.
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The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans
TL;DR: This review summarizes recent work that reveals new targets of the cAMP/protein kinase A pathway, new phenotypic consequences of signaling defects, and a more detailed understanding of connections with other aspects of cryptococcal biology including iron regulation, pH sensing, and stress.
Lithium treatment effects on Myo-inositol in adolescents with bipolar depression.
Nick C. Patel,Nick C. Patel,Melissa P. DelBello,Kim M. Cecil,Caleb M. Adler,Holly S. Bryan,Kevin E. Stanford,Stephen M. Strakowski +7 more
TL;DR: It is demonstrated that prefrontal mI concentrations do not significantly change from baseline after acute and chronic lithium treatment in adolescents with bipolar depression, indicating possible mechanisms by which lithium exerts antidepressant activity.
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Phosphorylation regulates myo-inositol-3-phosphate synthase a novel regulatory mechanism of inositol biosynthesis
TL;DR: The findings identify a novel mechanism of regulation of inositol synthesis by phosphorylation of MIPS, which may explain the causes and consequences of perturbation ofInositol metabolism implicated in human disorders.
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Inositol Phosphates and Phosphoinositides in Health and Disease
TL;DR: Questions to understand how inositol phosphates and PIs are compartmentalized will help clarify the mechanisms of the diseases associated with these molecules and identify new possibilities for drug design.
51
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Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania
Charles L. Bowden,Andrew M. Brugger,Alan C. Swann,Joseph R. Calabrese,Philip G. Janicak,Frederick Petty,Steven C. Dilsaver,John M. Davis,A. John Rush,Joyce G. Small,Enrique S. Garza-Treviño,S.Craig Risch,Paul J. Goodnick,David D. Morris,V.S. Shu,Philip C. Johnson,M. Blake,Martin A Javors,Larry Ereshefsky,Terry McLeod,Arif M. Shoaib,Mark H. Johnson,Susan E. Kimmel,A. Wesley,R. Qualtiere,C. Trivedi,J. I. Javaid,Jeremy C. Peterson,Michael T. Lambert,Martin D. Zielinski,Paul J. Orsulak,L. Sharp,L. Akers,Marvin J. Miller,Jeffrey J. Kellams,G. Woodham,Alan Frazer +36 more
TL;DR: Divalproex was as effective in rapid-cycling manic patients as in other patients and appears to be independent of prior responsiveness to lithium, while lithium was significantly more effective than placebo in reducing the symptoms of acute mania.
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Affective disorders in five United States communities.
Myrna M. Weissman,Philip J. Leaf,Gary L. Tischler,Dan G. Blazer,Marvin Karno,Martha L. Bruce,Louis P. Florio +6 more
TL;DR: Results on the age/sex specific prevalence of DSM-III affective disorders from the NIMH Epidemiologic Catchment Area Study (ECA), a probability sample of over 18,000 adults from five United States communities, are presented.
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