Journal Article10.1016/S0378-4347(00)80646-5
Isolation of basic drugs from plasma using solid-phase extraction with a cyanopropyl-bonded phase.
Greet Musch,Desire Massart +1 more
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TL;DR: The use of a CN sorbent for the isolation of basic compounds from plasma is described and it was found that compounds with a carbon chain length greater than or equal to 11 are totally retained and that the competitive effect of the matrix on the adsorption is minimal.
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About: This article is published in Journal of Chromatography B: Biomedical Sciences and Applications. The article was published on 01 Jan 1988. The article focuses on the topics: Solid phase extraction.
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Citations
A single-column procedure on Bond Elut Certify for systematic toxicological analysis of drugs in plasma and urine.
TL;DR: A single-column solid-phase extraction procedure was developed for the screening of acidic, neutral, and basic drugs from plasma and the recoveries of all 25 tested drugs exceeded 82%.
81
Determination of floral fragrances of Rosa hybrida using solid-phase trapping-solvent extraction and gas chromatography-mass spectrometry.
TL;DR: Floral fragrances emanated from Rosa hybrida were determined by solid-phase trapping extraction and GC-MS and endocrine disruptors such as bis(2-ethylhexyl) phthalate were detected simultaneously.
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Comparison of new solid-phase extraction methods for chromatographic identification of drugs in clinical toxicological analysis
TL;DR: The new solid-phase extraction technologies offer advantages in different respects: the mixed-phase disc extraction SPEC 1 Plus AR/MP3 Multi-Modal delivers promising results with respect to broad-spectrum general screening and headspace sampling by SPME offers a good alternative to conventional mechanized sampling in the analysis of volatile substances in biological samples, omitting the need for expensive instrumentation.
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Sol-gel immobilized cyano-polydimethylsiloxane coating for capillary microextraction of aqueous trace analytes ranging from polycyclic aromatic hydrocarbons to free fatty acids.
TL;DR: For the first time when a CN-PDMS thick coating survived such a high operation temperature, detection limits of nanogram/liter (ng/L) were achieved for both highly polar and nonpolar analytes directly extracted from aqueous media using sol-gel CN- PDMS coated microextraction capillaries followed by GC analysis.
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Solid-phase extraction technique for the analysis of biological samples
T.R. Krishnan,I. Ibraham +1 more
TL;DR: This article reviews the literature on solid-phase extraction published in the last 10 years and emphasis has been placed on dealing with samples of biological origin.
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References
Liquid-solid sample preparation in drug analysis.
TL;DR: The commercially available manual LSE methods, Sep-Pak and Bond Elut, as well as the automated instruments Prep and Analytichem Automated Sample Processor (AASP), are reviewed.
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Separation strategy of multicomponent mixtures by liquid chromatography with a single stationary phase and a limited number of mobile phase solvents
TL;DR: Divers medicaments et additifs alimentaires sont separes, soit en phase normale, and en phase inverse as mentioned in this paper, soit in phase inverse.
59
Expert system for pharmaceutical analysis : II. Relative contribution of and rule validation for amperometric detection (oxidation mode)
Greet Musch,Desire Massart +1 more
TL;DR: In this paper, the expert system predicted correctly whether a drug could be detected with an amperometric detector (oxidation mode) in 93% of the compounds investigated and the validation was performed for drugs possessing a low molar extinction coefficient and for pharmaceuticals containing only small amounts of drugs.
25
Dynamically-modified silica--an alternative to reversed-phase high-performance liquid chromatography on chemically bonded phases.
TL;DR: An alternative to the well known reversed-phase separations on chemically-bonded phases has been developed based on a dynamic modification of bare silica with long chain quaternary ammonium ions, which results in a high degree of reproducibility of the selectivity between solutes.
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Direct injection of biological fluids: Application of HPLC-analysis with precolumn enrichment to the pharmacokinetic studies of lonazolac
TL;DR: In this article, the p-hydroxylated metabolite M1 was determined in serum by high performance liquid chromatography using direct injection of comparatively large volumes with precolumn enrichment.
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