Conformational Changes Associated with Template Commitment in ATP-Dependent Chromatin Remodeling by ISW2
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TL;DR: Distinct stages in ATP-dependent chromatin remodeling are found as ISW2, an ISWI-type complex, forms a stable and processive complex with nucleosomes upon hydrolysis of ATP.
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About: This article is published in Molecular Cell. The article was published on 10 Jul 2009. and is currently open access. The article focuses on the topics: Chromatin structure remodeling (RSC) complex & ATP-dependent chromatin remodeling.
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Citations
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms
TL;DR: The mechanistic bases underlying the genetic requirements for BAF and other chromatin remodelers in development and cancer are relatively unexplored and will be a focus of this review.
Structure of RCC1 chromatin factor bound to the nucleosome core particle
Ravindra D. Makde,Ravindra D. Makde,Joseph R. England,Joseph R. England,Hemant P. Yennawar,Song Tan +5 more
TL;DR: The crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle is determined at 2.9 Å resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of theucleosome.
The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor
TL;DR: It is proposed that the chromodomains allow Chd1 to distinguish between nucleosomes and naked DNA by physically gating access to the ATPase motor, and it is hypothesize that related ATPase motors may employ a similar strategy to discriminate among DNA-containing substrates.
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Dynamics of nucleosome remodelling by individual ACF complexes.
Timothy R. Blosser,Timothy R. Blosser,Janet G. Yang,Michael D. Stone,Michael D. Stone,Geeta J. Narlikar,Xiaowei Zhuang,Xiaowei Zhuang +7 more
TL;DR: A single-molecule FRET study that monitors the remodelling of individual nucleosomes by ACF in real time, revealing previously unknown remodelling intermediates and dynamics.
Regulating the chromatin landscape: structural and mechanistic perspectives.
TL;DR: A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell development and differentiation and is being identified as targets in human diseases by NGS (next-generation sequencing).
References
Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome.
TL;DR: This study finds that chromatin remodeling by SWI/SNF and ISW2 involves DNA translocation inside nucleosomes two helical turns from the dyad axis at superhelical location-2.
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Chromatin remodeling: insights and intrigue from single-molecule studies
TL;DR: In this article, the authors present and discuss revised models for nucleosome sliding and ejection that integrate this new information with the earlier biochemical studies, while also challenging earlier concepts about loop formation, the character of the loop and how it propagates.
DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC.
Yongli Zhang,Carolyn L. Smith,Anjanabha Saha,Stephan W. Grill,Shirley S. Mihardja,Steven B. Smith,Bradley R. Cairns,Craig L. Peterson,Carlos Bustamante,Carlos Bustamante +9 more
TL;DR: Monitoring the real-time activity of single ySWI/SNF or RSC complexes on single, stretched nucleosomal templates under tensions above 1 pN suggests a nucleosome-remodeling mechanism through intranucleosomal DNA loop formation, which may provide a molecular basis for the biological functions of remodelers.
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The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing
TL;DR: The results indicate that ACF generates the characteristic 50- to 60-base-pair internucleosomal spacing in silent chromatin by kinetically discriminating against shorter linker DNAs.
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Mechanisms of ATP dependent chromatin remodeling.
TL;DR: The role of histone tails and their respective modifications in ATP-dependent remodeling are discussed and the biochemical properties and structural information of several of these remodeling complexes are reviewed.