Journal Article10.1177/0284185116639764
Apparent diffusion coefficient values are superior to transrectal ultrasound-guided prostate biopsy for the assessment of prostate cancer aggressiveness
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TL;DR: The ADC values of cancerous areas in the prostate are a better indicator than the biopsy GS in predicting prostate cancer aggressiveness and can help identify the presence of high-grade tumor in patients with a Gleason score during biopsy.
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Abstract: Background Few studies have focused on comparing the utility of diffusion-weighted imaging (DWI) and transrectal ultrasound (TRUS)-guided biopsy in predicting prostate cancer aggressiveness. Whether apparent diffusion coefficient (ADC) values can provide more information than TRUS-guided biopsy should be confirmed. Purpose To retrospectively assess the utility of ADC values in predicting prostate cancer aggressiveness, compared to the TRUS-guided prostate biopsy Gleason score (GS). Material and Methods The DW images of 54 patients with biopsy-proven prostate cancer were obtained using 1.5-T magnetic resonance (MR). The mean ADC values of cancerous areas and biopsy GS were correlated with prostatectomy GS and D'Amico clinical risk scores, respectively. Meanwhile, the utility of ADC values in identifying high-grade prostate cancer (with Gleason 4 and/or 5 components in prostatectomy) in patients with a biopsy GS ≤ 3 + 3 = 6 was also evaluated. Results A significant negative correlation was found between mean ADC values of cancerous areas and the prostatectomy GS ( P < 0.001) and D'Amico clinical risk scores ( P < 0.001). No significant correlation was found between biopsy GS and prostatectomy GS ( P = 0.140) and D'Amico clinical risk scores ( P = 0.342). Patients harboring Gleason 4 and/or 5 components in prostatectomy had significantly lower ADC values than those harboring no Gleason 4 and/or 5 components ( P = 0.004). Conclusion The ADC values of cancerous areas in the prostate are a better indicator than the biopsy GS in predicting prostate cancer aggressiveness. Moreover, the use of ADC values can help identify the presence of high-grade tumor in patients with a Gleason score ≤ 3 + 3 = 6 during biopsy.
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Citations
Correlations between Apparent Diffusion Coefficient and Gleason Score in Prostate Cancer: A Systematic Review.
TL;DR: A systematic review of studies using apparent diffusion coefficient for the prediction of Gleason score in prostate cancer patients found that in PC located in the peripheral zone, ADC correlated moderately with Gleasons score, and in PC location in the translational zone, ADC correlated weakly with Gle Mason score.
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The Apparent Diffusion Coefficient (ADC) is a useful biomarker in predicting metastatic colon cancer using the ADC-value of the primary tumor
Elias Nerad,Elias Nerad,Elias Nerad,Andrea Delli Pizzi,Doenja M. J. Lambregts,Monique Maas,Sharan Wadhwani,Frans C. H. Bakers,Harrie C. M. van den Bosch,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan,Max J. Lahaye +11 more
TL;DR: The ADC-value of the primary tumor has the potential to predict advanced colon cancer, defined as lymph node metastasis or distant metastasis, with lower ADC values significantly associated with advanced tumors, and increases the prediction accuracy of lymph nodes metastasis compared with morphological criteria.
Radiomics Models Based on Apparent Diffusion Coefficient Maps for the Prediction of High-Grade Prostate Cancer at Radical Prostatectomy: Comparison With Preoperative Biopsy
TL;DR: In this paper, the authors developed and tested radiomics models based on manually or automatically gained masks on apparent diffusion coefficient (ADC) maps to predict high-grade (Gleason score ≥ 4 + 3) PCa at radical prostatectomy (RP).
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Reduced field-of-view and multi-shot DWI acquisition techniques: Prospective evaluation of image quality and distortion reduction in prostate cancer imaging.
Edward M. Lawrence,Yuxin Zhang,Jitka Starekova,Zihan Wang,Ali Pirasteh,Shane A. Wells,Diego Hernando +6 more
TL;DR: In this article , the authors compared image quality and apparent diffusion coefficient (ADC) quantification for reduced field-of-view (rFOV)- and multi-shot echo-planar imaging (msEPI)-based diffusion weighted imaging (DWI), using single shot echoplanar-imaging (ssEPI) DWI as the reference.
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Fully automated detection and localization of clinically significant prostate cancer on MR images using a cascaded convolutional neural network
Ge Gao,Yi Zhu,Chao Han,Xiang-zheng Liu,Derun Li,Weipeng Liu,Xiangpeng Wang,Jingyuan Zhang,Xiaohong Zhang,Xiaoying Wang +9 more
TL;DR: The cascaded deep learning model trained with ADC and T2WI achieves good performance for automated csPCa detection and localization and has higher specificity than the ADC model.
References
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Prediction of Prognosis for Prostatic Adenocarcinoma by Combined Histological Grading and Clinical Staging
TL;DR: The data for stages III and IV patients with histologically low grade cancers suggest that these patients are at no greater risk of death from cancer than most stages I and II patients for whom radical prostatectomy has been recommended.
2.1K
Radical prostatectomy versus watchful waiting in early prostate cancer.
Anna Bill-Axelson,Anna Bill-Axelson,Lars Holmberg,Mirja Ruutu,Hans Garmo,Jennifer R. Stark,Jennifer R. Stark,Christer Busch,Stig Nordling,Michael Häggman,Swen-Olof Andersson,Stefan Bratell,Anders Spångberg,Juni Palmgren,Gunnar Steineck,Hans-Olov Adami,Hans-Olov Adami,Jan-Erik Johansson +17 more
TL;DR: Radical prostatectomy was associated with a reduction in the rate of death from prostate cancer, and men with extracapsular tumor growth may benefit from adjuvant local or systemic treatment.
1.9K
Cancer-Specific Mortality After Surgery or Radiation for Patients With Clinically Localized Prostate Cancer Managed During the Prostate-Specific Antigen Era
TL;DR: Evidence is provided to support the prediction of time to PCSM after surgery or radiation on the basis of pretreatment risk groups for patients with clinically localized prostate cancer managed during the PSA era.
488
Is apparent diffusion coefficient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images?
Baris Turkbey,Vijay Shah,Yuxi Pang,Marcelino Bernardo,Sheng Xu,Jochen Kruecker,Julia K. Locklin,Angelo A. Baccala Md,Ardeshir R. Rastinehad,Maria Merino,Joanna H. Shih,Bradford J. Wood,Peter A. Pinto,Peter L. Choyke +13 more
TL;DR: There is a significant negative correlation between ADCs and Gleason and D'Amico clinical risk scores, and ADCs may be useful in predicting the aggressiveness of prostate cancer.