Journal Article10.1016/S0301-0082(03)00050-9
Adenosine in the spinal cord and periphery: release and regulation of pain.
Jana Sawynok,Xue Jun Liu +1 more
368
TL;DR: The factors that regulate the extracellular availability of adenosine in the spinal cord and at peripheral sites are considered; and the extent to which thisAdenosine affects pain signalling in these two distinct compartments is considered.
read more
About: This article is published in Progress in Neurobiology. The article was published on 01 Apr 2003. The article focuses on the topics: Adenosine kinase & Adenosine A2B receptor.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.
Veli-Pekka Jaakola,Mark T. Griffith,Michael A. Hanson,Vadim Cherezov,Ellen Y.T. Chien,J. Robert Lane,Adriaan P. IJzerman,Raymond C. Stevens +7 more
TL;DR: The crystal structure of the human A2A adenosine receptor is determined, in complex with a high-affinity subtype-selective antagonist, ZM241385, to 2.6 angstrom resolution and suggests a role for ZM 241385 in restricting the movement of a tryptophan residue important in the activation mechanism of the class A receptors.
Physiology and Pathophysiology of Purinergic Neurotransmission
TL;DR: This review is focused on purinergic neurotransmission, i.e., ATP released from nerves as a transmitter or cotransmitter to act as an extracellular signaling molecule on both pre- and postjunctional membranes at neuroeffector junctions and synapses, as well as acting as a trophic factor during development and regeneration.
Immune and inflammatory mechanisms in neuropathic pain.
Gila Moalem,David J. Tracey +1 more
TL;DR: Some of the milestones in research that have led to an increased awareness of the contribution of immune and inflammatory systems to neuropathic pain are reviewed and the role of immune cells and inflammatory mediators are reviewed.
806
Adenosine and Brain Function
TL;DR: Much additional work is needed to pinpoint the sites and mechanisms of action, as well as the roles in chronic pain states of adenosine A 2A receptors in neurodegenerative disorders and ARs in psychiatric disorders.
731
GLIA: A novel drug discovery target for clinical pain
Linda R. Watkins,Steven F. Maier +1 more
TL;DR: This review examines the evidence for glial regulation of nociception and pharmacological approaches that might successfully control glially driven clinical pain syndromes.
699
References
Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage
Michael Mayne,Julie Fotheringham,Hui Jin Yan,Christopher Power,Marc R. Del Bigio,James Peeling,Jonathan D. Geiger +6 more
TL;DR: Results suggest that pharmacological strategies targeting A2A receptors may provide effective inhibition of acute neurotoxic proinflammatory events that occur following intracerebral hemorrhage.
147
Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation
Peter J. Gebicke-Haerter,Florian Christoffel,Jens Timmer,Hinnak Northoff,Mathias Berger,Dietrich van Calker +5 more
TL;DR: In this paper, the authors determined the proliferation of microglia by incorporation of [3H]thymidine into microglial DNA after stimulation with adenosine A1- and A2-receptor agonists.
144
The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine.
TL;DR: Results indicate that the antiinflammatory actions of GP-1-515 are mediated by adenosine, a novel strategy for the treatment of inflammatory diseases such as rheumatoid arthritis.
144
Presynaptic A1 inhibitory/A2A facilitatory adenosine receptor activation balance depends on motor nerve stimulation paradigm at the rat hemidiaphragm.
TL;DR: It is suggested that high-intensity, high-frequency motor nerve stimulation critically influences endogenous adenosine formation and the A1/A2Aceptor agonist R-N6-phenylisopropyladenosine was significantly attenuated in both stimulation conditions.
141
Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation
TL;DR: The present results identify one adenyl compound thus released, namely ATP, and identify astrocytes as one source and the release is brought about by activation of any of the three ionotropic glutamate receptor types-N-methyl-D-aspartate, AMPA and kainate receptors.
138