Showing papers in "Pathology in 2021"
TL;DR: In this article, the authors discuss the key practical issues relating to the implementation of PD-L1 testing for solid tumours in a pathology laboratory, including evidence for PD-l1 testing, different assay types, the potential interchangeability of PD L1 antibody clones and staining platforms, scoring criteria for PD L 1, validation, quality assurance, and pitfalls in PDL1 assessment.
186 citations
TL;DR: The recently published 5th edition 2019 World Health Organization (WHO) Classification of Tumours of the Digestive System brings significant changes from the 2010 4th edition as mentioned in this paper, with an emphasis on uniformity in nomenclature and grading for tumours across all organ systems.
84 citations
TL;DR: For the future, it would be desirable to create a category of 'oncocytic/chromophobe RCC, NOS' with the potential of further molecular studies for identification of TSC1/2 mutations in these rare tumours.
51 citations
TL;DR: It would be reasonable to reclassify this entity as a benign or low malignant potential neoplasm using the nomenclature of the extrarenal counterparts, clear cell papillary (cyst)adenoma is proposed.
46 citations
TL;DR: In this paper, the authors measured the circulating plasma miR-155 expression level in COVID-19 patients and healthy controls to investigate its roles in the pathogenesis and severity of CoV-19 disease and to assess its usefulness as a clinical biomarker for the detection of COVID19 diseases and the severity of infection.
42 citations
TL;DR: In this article, NAB2-STAT6 fusion variants are associated with distinct clinicopathological and molecular characteristics and have prognostic significance in extrameningeal solitary fibrous tumours.
40 citations
TL;DR: The classification of microvascular invasion within the renal sinus requires clarification, as does the prognostic significance of tumour in small vessels within the kidney.
38 citations
TL;DR: The concept of molecular classification and immunophenotypes, and their morphological features, which are easily interpreted and amenable to daily practice via hematoxylin and eosin staining are described, and the clinical advantages and limitations encountered while using these in routine clinical practice are considered.
31 citations
TL;DR: A comprehensive overview of the current knowledge of molecular aspects of prostate cancer and their potential utility in the context of different therapeutic approaches is provided.
26 citations
TL;DR: Although there is clear association with the likelihood of HIT, the 4T score had less utility than literature suggests, and was comparable to a previous study reported by some of the authors.
25 citations
TL;DR: The results of the SP263 assay using CPS1 showed the highest agreement between the biopsy and resection specimens, suggesting SP263 may provide the most representative approach for the evaluation of PD-L1 status in gastric cancer.
TL;DR: In this paper, the role and antitumour effects of HADHB expression in malignant lymphoma were investigated, and it was shown that HADHA was frequently overexpressed in high-grade lymphoma subtypes.
TL;DR: In this article, a large set of varied plasma samples comprising both quantitative von Willebrand factor deficiency (type 1 and 3) vs qualitative defects (type 2) tested in a cross-laboratory setting have been evaluated to assess contemporary von Willembrand factor assays for utility to differentially identify sample types.
TL;DR: The revised fourth edition of the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues (2017) reflects significant advances in understanding the biology, genetic basis and behaviour of haematopyic neoplasms as mentioned in this paper.
TL;DR: In this article, the analytical bias among five widely used commercial ferritin assays in Australia was evaluated and compared using data mining approach, functional reference limits for Siemens, Abbott, Beckman Coulter, Roche, Siemens and Ortho were derived and compared.
TL;DR: In this paper, the authors conducted a multicentre cross-sectional observational study of laboratory, public health and hospitalisation data for PCR-confirmed COVID-19 cases within the New Zealand Northern Region, between 12 February and 8 June 2020.
TL;DR: The association between high ANXA2 expression and prostate tumours of higher grade (GG 4-5) and stage (pT 3-4) suggests a potential use for ANxA2 as a prognostic biomarker of aggressive prostate cancer.
TL;DR: The data supported the usefulness of INSM1 in detecting neuroendocrine differentiation in IBC and suggested a favourable prognostic impact; thus, it could be useful for stratifying neuro endocrine tumours with different prognosis.
TL;DR: The detection or quantification of circulating CAR-T can be clinically useful, and is achieved through both direct methods, if available, or indirect/surrogate methods.
TL;DR: In this article, the potential impact of macrotroponin on the use of circulating cardiac troponin (cTn) as a long-term prognostic marker was investigated.
TL;DR: This review will focus on acute leukaemia, multiple myeloma and lymphoma and the potential diagnostic and prognostic implications of cfDNA, its role in response assessment and in detection of disease relapse.
TL;DR: A variety of entities that may be diagnostically challenging and emphasise the importance of identifying key morphological features that have diagnostic utility are discussed.
TL;DR: In this paper, the diagnostic and prognostic value of NGS panel testing in Philadelphia-negative myeloproliferative neoplasms: polycythaemia vera, essential thrombocythaemia, primary myelofibrosis, chronic neutrophilic leukaemia, systemic mastocytosis, and chronic eosinophilic leukemiaemia.
TL;DR: Diagnostic criteria, common pitfalls, and different histological patterns of invasion into the lamina propria are outlined.
TL;DR: It is speculated that defenestration can be a protective mechanism in simple steatosis which is lacking in NASH, and was more common in noNASH compared to NASH in human liver samples.
TL;DR: In this paper, the authors present a review of emerging testing technologies for detection of SARS-CoV-2, including those that are rapid and can be used at point-of-care (POC), and those facilitating high throughput laboratory-based testing.
TL;DR: In this paper, the authors highlight the progress made to date in machine learning applications in haematopathology, summarise important studies in this field, and highlight key limitations.
TL;DR: In this article, the authors investigated the number of CD68-positive TAMs and expression of programmed cell death-ligand 1 (PD-L1) in lymph node specimens from HL patients and correlated expression with clinical features (HIV status, disease severity and survival) and histopathological features (EBV latent positivity and subtype of HL).