Journal• ISSN: 1354-523X
Oral Diseases
Wiley
About: Oral Diseases is an academic journal published by Wiley. The journal publishes majorly in the area(s): Medicine & Biology. It has an ISSN identifier of 1354-523X. Over the lifetime, 4032 publications have been published receiving 100242 citations.
Topics: Medicine, Biology, Internal medicine, Periodontitis, Chemistry
Papers published on a yearly basis
Papers
TL;DR: This review considers some current areas of difficulty and controversy in the diagnosis and management of salivary gland tumours, which are best managed in specialist centres.
Abstract: Salivary gland tumours are a relatively rare and morphologically diverse group of lesions Although most clinicians and pathologists will have encountered the more common benign neoplasms, few have experience of the full range of salivary cancers, which are best managed in specialist centres This review considers some current areas of difficulty and controversy in the diagnosis and management of these neoplasms The classification of these lesions is complex, encompassing nearly 40 different entities, but precise classification and terminology is essential for an accurate diagnosis and for the allocation of tumours to prognostic groups For many salivary tumours diagnosis is straightforward but the wide range of morphological diversity between and within tumour types means that a diagnosis may not be possible on small incisional biopsies and careful consideration of the clinical and pathological features together is essential Although tumour grading is important and helpful, it is not an independent prognostic indicator and must be considered in the context of stage Large malignancies tend to have a poor prognosis regardless of grade and even high-grade neoplasms may do well when they are small A helpful guide to management of salivary cancers is the '4 cm rule'
910 citations
TL;DR: This mini-review, primarily dealing with the defensive systems in saliva, will focus on mucous oral epithelia and the protective functions of the peptides and of the (glyco)proteins of the innate immune system, contributing to the ®rst line of oral defence.
746 citations
TL;DR: The isolation of miRNAs from easily and non-invasively obtained Salivary exosomes with subsequent characterization of the miRNA expression patterns is promising for the development of future biomarkers of the diagnosis and prognosis of various salivary gland pathologies.
Abstract: Objective
To examine the presence of microRNAs within exosomes isolated from human saliva and to optimize and test methods for successful downstream applications.
741 citations
TL;DR: The role of human saliva and its compositional elements in relation to the GI functions of taste, mastication, bolus formation, enzymatic digestion, and swallowing is reviewed.
Abstract: Saliva has multiple essential functions in relation to the digestive process taking place in the upper parts of the gastrointestinal (GI) tract This paper reviews the role of human saliva and its compositional elements in relation to the GI functions of taste, mastication, bolus formation, enzymatic digestion, and swallowing The indirect function of saliva in the digestive process that includes maintenance of an intact dentition and mucosa is also reviewed Finally, pathophysiological considerations of salivary dysfunction in relation to some GI functions are considered
732 citations
TL;DR: It is recommended the establishment of a global research consortium to further study the natural history of OPMDs based on the classification and nomenclature proposed here, and link them to evidence-based interventions, to facilitate the prevention and management of lip and oral cavity cancer.
Abstract: Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a workshop held by the World Health Organization (WHO) Collaborating Centre for Oral Cancer in the UK. The first workshop held in London in 2005 considered a wide spectrum of disorders under the term "potentially malignant disorders of the oral mucosa" (PMD) (now referred to as oral potentially malignant disorders: OPMD) including leukoplakia, erythroplakia, proliferative verrucous leukoplakia, oral lichen planus, oral submucous fibrosis, palatal lesions in reverse smokers, lupus erythematosus, epidermolysis bullosa, and dyskeratosis congenita. Any new evidence published in the intervening period was considered to make essential changes to the 2007 classification. In the current update, most entities were retained with minor changes to their definition. There is sufficient evidence for an increased risk of oral cancer among patients diagnosed with "oral lichenoid lesions" and among those diagnosed with oral manifestations of 'chronic graft-versus-host disease'. These have now been added to the list of OPMDs. There is, to date, insufficient evidence concerning the malignant potential of chronic hyperplastic candidosis and of oral exophytic verrucous hyperplasia to consider these conditions as OPMDs. Furthermore, due to lack of clear evidence of an OPMD in epidermolysis bullosa this was moved to the category with limited evidence. We recommend the establishment of a global research consortium to further study the natural history of OPMDs based on the classification and nomenclature proposed here. This will require multi-center longitudinal studies with uniform diagnostic criteria to improve the identification and cancer risk stratification of patients with OPMDs, link them to evidence-based interventions, with a goal to facilitate the prevention and management of lip and oral cavity cancer.
697 citations
Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 27 |
| 2025 | 317 |
| 2024 | 376 |
| 2023 | 357 |
| 2022 | 381 |
| 2021 | 516 |