TL;DR: It is observed that HLA-G mRNAs having the 92-base deletion are more stable than the complete mRNA forms, suggesting that this region may be involved in the mechanisms controlling post-transcriptional regulation of Hla-G molecule associated with allelic variants.

TL;DR: It was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) and a request has been made by the International Union of Immunological Societies to provide a standardized nomenclature for the expressed protein products of the KIR genes.

TL;DR: The detection of HLA-G protein in adult corneas leads to the conclusion that this protein may contribute to the maintenance of the privileged immune status of cornea.

TL;DR: These new monoclonal antibodies represent valuable tools to study the expression of HLA-G and Hla-E molecules in cells and tissues under normal and pathologic conditions.

TL;DR: It is proposed that HLA-G may serve to monitor transplant patients who are likely to accept their allograft and, thus, may benefit of a reduced immunosuppressive treatment.

TL;DR: The results from this study suggest that anti-HLA class I alloantibodies may play an important role in the pathogenesis of BOS by inducing proliferation, growth factor production, and apoptotic cell death in AECs.

TL;DR: The phenotypic changes that occur in patients with heart transplants are identified and new avenues for the induction of specific immunosuppression in transplantation are opened.

TL;DR: It is indicated that CMV-specific cellular immune responses restricted by HLA-B*07 dominate those restricted byHLA-A*02 in both immunocompetent and Immunocompromised individuals.

TL;DR: The number of HLA-G5 specific spots was significantly increased primarily in monocytes compared with T and B cells, which suggests that peripheral blood monocytes are the predominant cells secreting HLA -G5.

TL;DR: The presence of mRNA for one of the two known soluble forms of Qa-2 in eight-cell embryos and in blastocysts is demonstrated and represents a model for potential therapy involving HLA-G.

TL;DR: The findings suggest that a genetically determined control of the HCV-induced inflammatory response may play a role in the resolution of HCV infection.

TL;DR: The developments in adoptive T cell immunogenetic therapy are summarized and the limitations and perspectives to improve this technology toward clinical application are discussed.

TL;DR: It is concluded that specific HLA class I alleles, combined with certain HPV16 E6 variants, may be crucial for immune surveillance in cervical carcinogenesis and helpful in defining prognostic markers and in designing vaccines capable of mediating immune protection against HPV infection.

TL;DR: An indirect way of HLA-G5 action on DC occurring via T lymphocytes that reinforces the immune inhibitory role of soluble Hla-G capable to be secreted during tumoral malignancies or following heart transplantation is demonstrated.

TL;DR: The frequency of the sHLA-G secretion associated to its inhibiting role on T cells and natural killer cells during tumoral lymphoid malignancies suggests a potential role of these molecules as escape mechanism from antitumoral response.

TL;DR: Competition-based peptide binding assays for 13 prevalent human leukocyte antigen (HLA) class I alleles identified novel HLA class I high-affinity binding peptides from HIVpol, p53, PRAME, and minor histocompatibility antigen HA-1.

TL;DR: This study demonstrates that the decreased antigen presenting ability of monocytes in HIV(+) individuals is in part due to the upregulation of ILT4 on the monocytes caused by the elevated serum IL-10 levels seen in these individuals.

TL;DR: The presence of the FcRn receptor was also found in the metastasizing epithelial cells within the lymph nodes, and this provides a useful marker for their identification.

TL;DR: It is speculated that, in some situations, an infant with an unfavorable IL-10 genotype may exhibit aberrant IL- 10 production, which in turn leads to an imbalance in the immune response and renders the infant unable to cope with the infection.

TL;DR: The frequency of KIR loci combined with the linkage disequilibrium values suggest that the Greek population shares several general features with other Caucasoid populations studied before, but still distinguishes itself by the increased or decreased frequency of several alleles.

TL;DR: NFkappaB regulates inversely the expression of ICAM-1 and MHC class I antigens on HEp2 tumor cells and this may contribute to the resistance of these cells to NK cell mediated cytotoxicity.

TL;DR: It is concluded that significant differences exist with respect to the distribution of NK cells in term decidua basalis and parietalis and future functional studies may improve the understanding of their role at the maternal-fetal interface.

TL;DR: The polymorphisms of cytokine genes, which had been previously reported to be associated with a number of immune diseases, transplant complications, and direct or indirect influences on the level of expression and production, were investigated in 311 unrelated healthy Korean individuals.

TL;DR: The study investigated the relationships between HLA class II alleles and lupus nephritis in Italian patients and found that the HLA-DRB1*1501 greatly enhanced the risk of developing LN conferred by the D QA1*0101 allele, whereas DQA1-0102 suppressed the nephritogenic effect of DRB1-1501.

TL;DR: Because beta(2)m-freeCD1d HC were expressed on cells, the lack of cleaved soluble products cannot be explained by high stability of native complexes, and absence of a CD1d-specific MPase in these cells or its impaired interactions with substrate HC may be responsible.

TL;DR: The results suggest that the exon 4 variation site in human Tim-1 gene is associated with the susceptibility of allergic disease.

TL;DR: It is concluded that HLA-DR1 is associated with genetic susceptibility to UC in the Mexican Mestizo population and distinguishes a subgroup of patients with extensive colitis and the Hla-DRB1*0103 allele distinguishes asubgroup of severe form of disease that might require surgical management.

TL;DR: The TNFR1 gene region might be a susceptible locus to type 1 diabetes in Japanese after two-locus analysis with HLA class II alleles and the significantly increased frequency of the -383C allele, located in the TNFR-1 promoter region, is detected.

TL;DR: Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes, which implies genetic heterogeneity of MS.