TL;DR: The histochemical demonstration of nonspecific acid α-naphthyl acetate esterase (ANAE) activity was evaluated as a T lymphocyte marker primarily with the sheep erythrocyte (E) assay, and a distinctive staining pattern characterized T lymphocytes which could be readily distinguished from monocytes.

TL;DR: The data suggest that some lymphocyte subpopulations may be stimulated directly by products of other lymphocyte populations in the absence of any mitogenic signal.

TL;DR: Purified peripheral blood T lymphocytes from healthy donors were examined for the effect of thymopoietin, corticosteroids, and irradiation on cells with receptors for IgM (Tμ) and for IgG (Tγ).

TL;DR: The PMA induced supernatant LAF had a molecular weight of 16,000 daltons and exhibited charge heterogenity on DEAE cellulose and should be a useful tool with which to probe the biology and biochemistry of LAF.

TL;DR: Exogenously added histamine in non-cytotoxic concentrations (10−5−10−3M) suppresses in vitro proliferation of lymphocytes induced by PHA or Concanavalin A and does not cause increased release of isotope from 51Cr-labeled lymphocytes following 4 hr of incubation.

TL;DR: The data suggest that the immunoenhancing effect of Type II interferon on antibody responses is produced by an effect on T lymphocytes in contrast with the immunosuppressive effect which appears to be mediated through aneffect on B lymphocytes.

TL;DR: In this paper, the authors found that feeding mice sheep erythrocytes (SRBC) caused a significant decrease in splenic IgM antibody responses to SRBC given ip. Suppression of IgM responses by serum from fed mice was antigen-specific and not H-2 restricted.

TL;DR: Evidence supports the suggestion of a mechanism in which tumor cells may prevent the effect of a cellular immune response by producing inhibitory levels of prostaglandins and suggests that manipulation of this mechanism can enhance the effectiveness of the lymphocyte response.

TL;DR: The receptors for IgM on Tμ cells appear to be masked by passively absorbed IgM and require prior in vitro incubation in medium containing fetal calf serum for the full expression of this marker.

TL;DR: It is concluded that cells bearing histamine receptors may serve a regulatory role in cellular immunity after their activation by histamine by producing a non-dialyzable factor with immunosuppressive properties.

TL;DR: Resting macrophages were transformed as evidenced by functional criteria to activated cells by exposure to partially-purified or crude interferon (IF) preparations as well as a novel form of tissue immunity endowed by IF-inducers.

TL;DR: Despite normal inflammatory reactions, normal production of lymphokines and extensive experimental manipulation of single activation stimuli, macrophages from C3H/HeJ mice did not express tumoricidal activity in vitro, suggesting that the ultimate expression of macrophage cytotoxicity may depend upon certain signals from the milieu of immune reactions.

TL;DR: This study demonstrates that materials with LT activity in supernatants from PHA activated human lymphocytes in vitro are very heterogeneous.

TL;DR: The results collectively indicate that the immunological resistance against tumors is dependent on the balance of activations of the cytotoxic and suppressor T cells with different specificities and phenotypic expressions.

TL;DR: A dual-recognition model of restrictive recognition is proposed within the framework of the associative recognition (“two-signal”) theory, which deals with the finding that effector T-cell inhibitory and cytotoxic activity are K/D-restricted whereas effectorT-cell cooperating activity and delayed-hypersensitivity are I-restricted.

TL;DR: Spleen cells of C57BL/6 mice produced high amounts of PGE in vitro when tested 5 to 10 days after injection of heat-killed C. parvum organisms.

TL;DR: Tests demonstrated that the presence of IgA paraproteins inhibited PMN ingestion of IgG coated latex particles which could account for their effect on PMN bactericidal activity.

TL;DR: Macrophage activation factor was isolated from PPD-stimulated, BCG-immune mouse spleen cell culture fluids and was eluted by an increase in ionic strength, and was destroyed by proteolytic enzymes.

TL;DR: Both column passed and adherent T cells were further separated according to their ability to bind IgG or IgM immune complexes, showing that those mediating NK have receptors for IgG (Tγ+) but not for IgM (Tμ+).

TL;DR: The human histiocytic lymphoma cell line U937 was evaluated as a possible source of LAF, and although exhibiting several monocyte-specific properties, the U 937 cell line failed to release LAF.

TL;DR: The period required for the hypertrophy and change of orientation of Golgi apparatus is supposed to represent the “mobilization” step of a medium-sized and small killer lymphocyte.

TL;DR: It is indicated that thymus-dependent immune functions are critical determinants of host resistance to murine Cryptococcosis.

TL;DR: In this paper, the cell types involved in autologous mixed lymphocyte reactions (AMLR) were determined by separating peripheral leucocytes from normal donors into T-cell and B-cell enriched populations and subsequent co-culture of T cells and mitomycin-C inactivated non-T cells.

TL;DR: Spleen cells of CS7BL/6 mice and spleen cells treated by anti-θ serum plus complement did not differ from their respective controls, indicating that production of IF did not require mature T lymphocytes and requires the help of macrophages.

TL;DR: Granulomas isolated from the livers of CBA/J mice infected for 8 weeks with Schistosoma mansoni produced a chemotactic activity for eosinophils, in a manner which correlated with the production of the lymphokine eOSinophil stimulation promoter (ESP).

TL;DR: Thoracic duct lymphocytes drained from donors on the tenth day of a primary infection conferred greater protection against adult worms established by larval infection than either mesenteric lymph node cells (MLNC) or TDL drained from hyperimmune donors.

TL;DR: It is concluded that the previously demonstrated relationship between EBV receptors and complement receptors on B-lymphoblastoid lines also holds for peripheral B lymphocytes, where virus absorption is followed by an intracellular infectious process, signaled by the appearance of EBNA and cellular DNA synthesis.

TL;DR: After 30 to 60 min interaction with a target cell the fusion of “secretory” granules and crystal-like structures with lipids, mitochondrion degeneration, hypertrophy and reorientation of the Golgi apparatus toward the contact zone with atarget cell were observed.