Showing papers in "Blood in 1994"
6,260 citations
TL;DR: The results indicate that the phase in apoptosis that is characterized by chromatin condensation coincides with phosphatidylserine exposure, which precedes membrane damage that might lead to release from the cells of enzymes that are harmful to the surrounding tissues.
2,532 citations
TL;DR: In vitro studies showed the ability of C2B8 to bind human C1q, mediate complement-dependent cell lysis of human B-lymphoid cell lines, and lyse human target cells through antibody-dependent cellular cytotoxicity and the possibility of using an "immunologically active" chimeric anti-CD20 antibody as an alternative approach in the treatment of B-cell lymphoma.
2,226 citations
TL;DR: Leukocyte-endothelial adhesion molecules research has yielded significant progress in understanding the molecular basis of leukocyte emigration. The adhesion molecules and their regulation are key targets for therapeutic intervention in inflammatory and immune diseases.
Abstract: Abstract In the 9 years since the last review on leukocyte and endothelial interactions was published in this journal many of the critical structures involved in leukocyte adherence to and migration across endothelium have been elucidated. With the advent of cell and molecular biology approaches, investigations have progressed from the early descriptions by intravital microscopy and histology, to functional and immunologic characterization of adhesion molecules, and now to the development of genetically deficient animals and the first phase I trial of “anti-adhesion” therapy in humans. The molecular cloning and definition of the adhesive functions of the leukocyte integrins, endothelial members of the Ig gene superfamily, and the selectins has already provided sufficient information to construct an operative paradigm of the molecular basis of leukocyte emigration. The regulation of these adhesion molecules by chemoattractants, cytokines, or chemokines, and the interrelationships of adhesion pathways need to be examined in vitro and, particularly, in vivo. Additional studies are required to dissect the contribution of the individual adhesion molecules to leukocyte emigration in various models of inflammation or immune reaction. Certainly, new adhesion structures will be identified, and the current paradigm of leukocyte emigration will be refined. The promise of new insights into the biology and pathology of the inflammatory and immune response, and the potential for new therapies for a wide variety of diseases assures that this will continue to be an exciting area of investigation.
1,740 citations
TL;DR: Observations indicate that G-CSF is indispensible for maintaining the normal quantitative balance of neutrophil production during "steady-state" granulopoiesis in vivo and also implicate G- CSF in "emergency"granulopOiesis during infections.
967 citations
TL;DR: The frequency of DVT/PE justifies controlled trials of primary prophylaxis in high-risk groups, and therapeutic trials to determine optimal treatment.
963 citations
TL;DR: In this article, the authors reviewed the more common and variable hematologic and clinical manifestations of the idiopathic hypereosinophilic syndrome (HES) and reviewed the therapies that may be used for HES.
925 citations
TL;DR: CD20+ B cells were rapidly and specifically depleted in the peripheral blood at 24 to 72 hours and remained depleted for at least 2 to 3 months in most patients, and were used to design a multiple-dose phase I/II study.
800 citations
TL;DR: The acute chest syndrome (ACS), a pneumonia-like illness in sickle cell patients, is one of the most frequent causes of their morbidity and hospitalizations, and a positive association between ACS rate and steady-state leukocyte count is found.
734 citations
TL;DR: The results of a prospective study of the incidence and risk factors for acute chest syndrome (ACS) in the CSSCD patient population were reported in this article. But the results of the study were limited to a subset of the patients who developed the disease.
657 citations
TL;DR: In trial ALL-BFM 86, the largest multicenter trial of the Berlin-Frankfurt-Münster (BFM) study group for childhood acute lymphoblastic leukemia, treatment response was used as an overriding stratification factor for the first time and the benefit of intensive reinduction therapy even for low-risk patients was confirmed.
TL;DR: WT1 is a new prognostic factor and a new marker for the detection of MRD in acute leukemia regardless of the presence or absence of tumor-specific DNA markers.
TL;DR: P53 mutations could induce drug resistance, at least in part, by interfering with normal apoptotic pathways in tumor cells, and are a strong prognostic indicator of response to chemotherapy and survival in AML, MDS, and CLL.
TL;DR: Evaluated reconstitution of CMV-specific T-cell responses in 47 bone marrow transplant (BMT) recipients and suggest that a delay in recovery of these responses as a result of ganciclovir prophylaxis may contribute to the occurrence of late CMV disease.
TL;DR: It is shown that it is possible to use a replication-incompetent safety-modified retrovirus in order to introduce DNA sequences into the hematopoietic cells of patients undergoing autologous bone marrow transplantation.
TL;DR: If autografting with PBPCs in malignant lymphoma with poor prognosis is being considered, mobilization and harvesting should be planned early after initial diagnosis to avoid exhaustion of hematopoiesis by cumulative toxicity.
TL;DR: Observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-inducedThrombocytopenia.
TL;DR: In this article, the authors showed that BCR-ABL fusion protein acts as an anti-apoptosis gene in CML cells and suggests that the effect is dependent on the abl kinase activity in this chimeric protein.
TL;DR: The problems of conventional prognostic scores that the authors observed in IFN-treated patients support the idea that IFN changes the natural course of CML, and whether and to what extent IFN is superior to HU appears to depend on the degree of WBC suppression by HU-therapy and on the risk profile of the patients.
TL;DR: Results show that shear stress is capable of enhancing the susceptibility of vWF to proteolytic cleavage and promotes vWF proteolysis in normal plasma at a site that generates the 140-KD/176-kD fragments, leading to a decrease in multimer size.
TL;DR: In this paper, the authors show that BCR-ABL fusion protein can be used as an anti-apoptosis gene in CML cells and suggests that the effect is dependent on the abl kinase activity in this chimeric protein.
TL;DR: There is a high proportion of patients with circulating tumor cells under steady-state conditions, and in addition a substantial risk of concomitant tumor cell recruitment upon mobilization of PBPCs, particularly in stage IV breast cancer patients with bone marrow infiltration.
TL;DR: The marker-gene technique described should permit evaluation of the mechanisms of relapse and the efficacy of purging in patients receiving autologous marrow transplantation for other solid tumors that infiltrate the marrow.
TL;DR: Mutations within the coding portion of the WAF1 gene were undetectable in a large series of human tumors, many of which had a normal p53 gene.
TL;DR: Based on the history of opportunistic complications in patients with other disorders who display similar degrees of CD4+ T-cell lymphopenia and preliminary observations in this population, immune incompetence could surface as a dose-limiting toxicity for highly dose-intensive chemotherapy regimens.
TL;DR: Risk of developing hematopoietic abnormalities was higher in persons with Fanconi anemia than in those without a prior clonal cytogenetic abnormality, and risk of death from hematologic causes was higher than in people without.
TL;DR: The Recombinate Study Group initiated a prospective, open-labeled investigation of recombinant factor VIII (r-FVIII) to assess its safety and efficacy and to characterize the natural history of inhibitor development in previously untreated patients with hemophilia A as mentioned in this paper.
TL;DR: It is concluded that HCV RNA levels are significantly higher in HIV+ than in HIV- multitransfused hemophiliacs, and this findings suggest that HIV-induced immune deficiency may promote increased HCV replication.
TL;DR: There is increasing pressure from various sources for the reduction of the leukocyte content in allogeneic blood components to minimize the occurrence of their adverse effects and to define the optimal conditions required for the preparation of blood components ultimately destined for clinical use.