Institution
AngloGold Ashanti
Company•Johannesburg, South Africa•
About: AngloGold Ashanti is a company organization based out in Johannesburg, South Africa. It is known for research contribution in the topics: Craton & Metamorphism. The organization has 146 authors who have published 161 publications receiving 3206 citations. The organization is also known as: ANGLOGOLD ASHANTI LIMITED.
Topics: Craton, Metamorphism, Zircon, Archean, Terrane
Papers published on a yearly basis
Papers
Harvard University1, Boston University2, Stellenbosch University3, AngloGold Ashanti4, University of Massachusetts Medical School5, Centers for Disease Control and Prevention6, University of Leicester7, Provincial Health Services Authority8, University of California, San Francisco9, Rutgers University10, Swiss Tropical and Public Health Institute11, University of Basel12, Broad Institute13
TL;DR: Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin, and evidence of positive selection in an additional 39 genomic regions in resistant isolates was found.
Abstract: M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains. By searching for convergent evolution--the independent fixation of mutations in the same nucleotide position or gene--we recovered 100% of a set of known resistance markers. We also found evidence of positive selection in an additional 39 genomic regions in resistant isolates. These regions encode components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways. Mutations in these regions could directly confer resistance or compensate for fitness costs associated with resistance. Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin.
471 citations
TL;DR: The objective of this paper is to report on the development of a prototype model for measuring information security awareness in an international mining company.
468 citations
Harvard University1, Stellenbosch University2, Boston University3, AngloGold Ashanti4, University of Massachusetts Medical School5, Centers for Disease Control and Prevention6, University of Leicester7, Provincial Health Services Authority8, University of California, San Francisco9, Rutgers University10, Swiss Tropical and Public Health Institute11, University of Basel12, Broad Institute13
TL;DR: In this article, the authors identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains of M. tuberculosis and identified positive selection in 39 genomic regions in resistant isolates, encoding components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways.
Abstract: M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains. By searching for convergent evolution--the independent fixation of mutations in the same nucleotide position or gene--we recovered 100% of a set of known resistance markers. We also found evidence of positive selection in an additional 39 genomic regions in resistant isolates. These regions encode components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways. Mutations in these regions could directly confer resistance or compensate for fitness costs associated with resistance. Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin.
315 citations
TL;DR: In this article, new tectonic-metallogenic subdivisions proposed in Tanzania are used to explain gold-endowment, assess gold exploration maturity, and suggest the potential for new discoveries from the following three regions: 1) the Lake Victoria Region, comprising the gold-endedowed East Lake Victoria and Lake Nyanza Superterranes of 3.11-Ga continental crust, and 2) the Central Tanzania Region, including the Moyowosi-Manyoni Superterrane, which is largely composed of granitoid and migmatitic-gneissic
97 citations
TL;DR: Characterization of the different species reveals that many are opportunistic organisms with an origin due to recharge from surface waters rather than soil leaching, and calculations suggest that food, not dissolved oxygen is the limiting factor for eukaryal population growth.
Abstract: Following the discovery of the first Eukarya in the deep subsurface, intense interest has developed to understand the diversity of eukaryotes living in these extreme environments. We identified that Platyhelminthes, Rotifera, Annelida and Arthropoda are thriving at 1.4 km depths in palaeometeoric fissure water up to 12,300 yr old in South African mines. Protozoa and Fungi have also been identified; however, they are present in low numbers. Characterization of the different species reveals that many are opportunistic organisms with an origin due to recharge from surface waters rather than soil leaching. This is the first known study to demonstrate the in situ distribution of biofilms on fissure rock faces using video documentation. Calculations suggest that food, not dissolved oxygen is the limiting factor for eukaryal population growth. The discovery of a group of Eukarya underground has important implications for the search for life on other planets in our solar system.
80 citations
Authors
Showing all 147 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Thomas G. Blenkinsop | 34 | 150 | 3703 |
| Stanislav Ulrich | 17 | 41 | 994 |
| M. G. Doyle | 12 | 16 | 1217 |
| Francky Fouedjio | 8 | 23 | 227 |
| Sylvester Segbaya | 7 | 9 | 150 |
| Salih Ramazan | 7 | 9 | 426 |
| Tony Roache | 5 | 5 | 137 |
| Michael Nugus | 5 | 13 | 96 |
| Alistair Calver | 4 | 4 | 817 |
| David P Roberts | 4 | 10 | 45 |
| J.M. Kabete | 3 | 4 | 126 |
| M. Nugus | 3 | 3 | 223 |
| Zahan Eloff | 3 | 5 | 64 |
| Ulisses Cyrino Penha | 3 | 7 | 21 |
| Paul J. Bartos | 3 | 5 | 51 |
Related Institutes (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2023 | 2 |
| 2022 | 1 |
| 2021 | 13 |
| 2020 | 10 |
| 2019 | 8 |
| 2018 | 8 |