7 Papers
Zixu Liu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immune receptor & Kinase. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Zixu Liu include Chinese Academy of Sciences & Wuhan University.
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Papers
Receptor-like Cytoplasmic Kinases Integrate Signaling from Multiple Plant Immune Receptors and Are Targeted by a Pseudomonas syringae Effector
Jie Zhang,Wei Li,Tingting Xiang,Zixu Liu,Kristin Laluk,Xiaojun Ding,Yan Zou,Minghui Gao,Xiaojuan Zhang,She Chen,Tesfaye Mengiste,Yuelin Zhang,Jianmin Zhou +12 more
TL;DR: Genetic and molecular analyses indicate that BIK1, and possibly PBL1, PBL2, and PBS1, integrate immune signaling from multiple immune receptors, and AvrPphB-mediated degradation of one of these kinases is monitored by RPS5 to initiate ETI.
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The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity.
Lei Li,Meng Li,Liping Yu,Zhaoyang Zhou,Xiangxiu Liang,Zixu Liu,Gaihong Cai,Liyan Gao,Xiaojuan Zhang,Yingchun Wang,She Chen,Jianmin Zhou +11 more
TL;DR: It is shown that the receptor-like cytoplasmic kinase BIK1, a component of the FLS2 immune receptor complex, not only positively regulates flg22-triggered calcium influx but also directly phosphorylates the NADPH oxidase RbohD at specific sites in a calcium-independent manner to enhance ROS generation.
766
Chitin-Induced Dimerization Activates a Plant Immune Receptor
Tingting Liu,Zixu Liu,Chuanjun Song,Yunfei Hu,Zhifu Han,Ji She,Fangfang Fan,Jiawei Wang,Changwen Jin,Junbiao Chang,Jianmin Zhou,Jijie Chai +11 more
TL;DR: The data support the notion that chitin-induced AtCERK1 dimerization is critical for its activation and suggest that the biological response requires dimerisation of the receptor when it binds a chit in oligomer at least seven or eight subunits long.
644
BIK1 interacts with PEPRs to mediate ethylene-induced immunity
TL;DR: It is shown that PEPR1 specifically interacts with receptor-like cytoplasmic kinases botrytis-induced kinase 1 (BIK1) and PBS1-like 1 (PBL1) to mediate Pep1-induced defenses, illustrating a mechanism by which ET and PEPR signaling pathways act in concert to amplify immune responses.
315
Shigella flexneri suppresses NF-κB activation by inhibiting linear ubiquitin chain ligation.
TL;DR: Loss of function studies in mammallian cells in combination with bacterial genetics explains how Shigella evades a broad spectrum of immune surveillance systems by cooperative inhibition of receptor ubiquitination and reveals the critical importance of LUBAC in host defence against pathogens.